2. PI3K/Akt/mTOR Protein Tyrosine Kinase/RTK JAK/STAT Signaling
  3. EGFR Akt mTOR
  4. Yuanhuadin

Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion.

For research use only. We do not sell to patients.

Yuanhuadin Chemical Structure

Yuanhuadin Chemical Structure

CAS No. : 76402-66-9

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Yuanhuadin Related Antibodies

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  • Biological Activity

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Description

Yuanhuadin, extracted from Genkwa Flos Daphne genkwa, has antitumor activity through inhibiting Akt/mTOR and EGFR pathways, induce cell-cycle arrest and abortion[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
> 50 μM
Compound: 9
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
Cytotoxicity against human A549 cells after 48 hrs by MTT assay
[PMID: 23558238]
A549 IC50
12 nM
Compound: 1
Antiproliferative activity against human A549 cells after 3 days by SRB assay
Antiproliferative activity against human A549 cells after 3 days by SRB assay
[PMID: 21916433]
B16 IC50
0.06 μM
Compound: 4
Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry
Inhibition of melanin production in alpha-MSH stimulated mouse B16 cells after 72 hrs by spectrophotometry
[PMID: 23623417]
B16 IC50
22 μM
Compound: 4
Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay
Cytotoxicity against alpha-MSH stimulated mouse B16 cells after 72 hrs by MTT assay
[PMID: 23623417]
HCT-116 IC50
10.2 μM
Compound: 1
Antiproliferative activity against human HCT116 cells after 3 days by SRB assay
Antiproliferative activity against human HCT116 cells after 3 days by SRB assay
[PMID: 21916433]
HCT-116 IC50
32.65 μM
Compound: 9
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
Cytotoxicity against human HCT116 cells after 48 hrs by MTT assay
[PMID: 23558238]
HeLa IC50
17.06 μM
Compound: 9
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
Cytotoxicity against human HeLa cells after 48 hrs by MTT assay
[PMID: 23558238]
HepG2 IC50
26.27 μM
Compound: 9
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
Cytotoxicity against human HepG2 cells after 48 hrs by MTT assay
[PMID: 23558238]
HL-60 IC50
30.05 μM
Compound: 9
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
Cytotoxicity against human HL60 cells after 48 hrs by MTT assay
[PMID: 23558238]
HT-1080 IC50
< 0.1 μM
Compound: 9
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
Cytotoxicity against human HT1080 cells after 48 hrs by MTT assay
[PMID: 23558238]
K562 IC50
22.16 μM
Compound: 9
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
Cytotoxicity against human K562 cells after 48 hrs by MTT assay
[PMID: 23558238]
LoVo IC50
> 10 μM
Compound: 10
Cytotoxicity against human LoVo cells after 24 hrs by MTT assay
Cytotoxicity against human LoVo cells after 24 hrs by MTT assay
[PMID: 32223193]
MCF7 IC50
4.11 μM
Compound: 9
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
Cytotoxicity against human MCF7 cells after 48 hrs by MTT assay
[PMID: 23558238]
MT4 CC50
> 6.8 μM
Compound: 14
Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay
Cytotoxicity against human MT4 cells incubated for 3 days by CellTiter-Glo luminescent assay
[PMID: 31860304]
NCI-H1299 IC50
5.6 μM
Compound: 1
Antiproliferative activity against human H1299 cells after 3 days by SRB assay
Antiproliferative activity against human H1299 cells after 3 days by SRB assay
[PMID: 21916433]
NCI-H1993 IC50
4.1 nM
Compound: 1
Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay
Antiproliferative activity against gefitinib resistant human NCI-H1993 cells after 3 days by SRB assay
[PMID: 21916433]
NCI-H1993 IC50
4.7 nM
Compound: 1
Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H1993 cells after 3 days by SRB assay
[PMID: 21916433]
NCI-H292 IC50
< 1 x 10-6 μM
Compound: 1
Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H292 cells after 3 days by SRB assay
[PMID: 21916433]
NCI-H292 IC50
< 1 x 10-6 μM
Compound: 1
Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay
Antiproliferative activity against gefitinib resistant human NCI-H292 cells after 3 days by SRB assay
[PMID: 21916433]
NCI-H358 IC50
9.1 μM
Compound: 1
Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay
Antiproliferative activity against human NCI-H358 cells after 3 days by SRB assay
[PMID: 21916433]
PC-3 IC50
7.4 μM
Compound: 1
Antiproliferative activity against human PC3 cells after 3 days by SRB assay
Antiproliferative activity against human PC3 cells after 3 days by SRB assay
[PMID: 21916433]
RKO IC50
> 10 μM
Compound: 10
Cytotoxicity against human RKO cells after 24 hrs by MTT assay
Cytotoxicity against human RKO cells after 24 hrs by MTT assay
[PMID: 32223193]
SK-HEP1 IC50
12.9 μM
Compound: 1
Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay
Antiproliferative activity against human SKHEP1 cells after 3 days by SRB assay
[PMID: 21916433]
SK-MES-1 IC50
< 1 x 10-6 μM
Compound: 1
Antiproliferative activity against human SK-MES cells after 3 days by SRB assay
Antiproliferative activity against human SK-MES cells after 3 days by SRB assay
[PMID: 21916433]
SNU-638 IC50
> 20 μM
Compound: 1
Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
Antiproliferative activity against human SNU638 cells after 3 days by SRB assay
[PMID: 21916433]
SW480 IC50
11.8 μM
Compound: 1
Antiproliferative activity against human SW480 cells after 3 days by SRB assay
Antiproliferative activity against human SW480 cells after 3 days by SRB assay
[PMID: 21916433]
SW-620 IC50
> 10 μM
Compound: 10
Cytotoxicity against human SW620 cells after 24 hrs by MTT assay
Cytotoxicity against human SW620 cells after 24 hrs by MTT assay
[PMID: 32223193]
T47D IC50
12.7 μM
Compound: 1
Antiproliferative activity against human T47D cells after 3 days by SRB assay
Antiproliferative activity against human T47D cells after 3 days by SRB assay
[PMID: 21916433]
U-937 IC50
14.66 μM
Compound: 9
Cytotoxicity against human U937 cells after 48 hrs by MTT assay
Cytotoxicity against human U937 cells after 48 hrs by MTT assay
[PMID: 23558238]
Molecular Weight

586.67

Formula

C32H42O10
CAS No.
SMILES

O=C1C(C)=C[C@@H]2[C@]3([C@H]4[C@H]5O[C@@]5([C@H]([C@@]12O)O)CO)O[C@]6(O[C@@]([C@@H](OC(C)=O)[C@H]3C)([C@H]4O6)C(C)=C)/C=C/C=C/CCCCC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Yuanhuadin Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Yuanhuadin76402-66-9EGFRAktmTOREpidermal growth factor receptorErbB-1HER1PKBProtein kinase BMammalian target of RapamycinCancerInflammationAbortionInhibitorinhibitorinhibit

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