2. Apoptosis
  3. Caspase
  4. Z-Ala-Ala-Asp-CMK

Z-Ala-Ala-Asp-CMK  (Synonyms: Z-AAD-CMK)

Cat. No.: HY-P10004 Purity: 98.14%
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Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor.

For research use only. We do not sell to patients.

Custom Peptide Synthesis

Z-Ala-Ala-Asp-CMK Chemical Structure

Z-Ala-Ala-Asp-CMK Chemical Structure

CAS No. : 183284-21-1

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1 mg USD 150 In-stock
5 mg USD 370 In-stock
10 mg USD 600 In-stock
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Based on 1 publication(s) in Google Scholar

Z-Ala-Ala-Asp-CMK Related Antibodies

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Description

Z-Ala-Ala-Asp-CMK (Z-AAD-CMK) is a selective granzyme B inhibitor[1].

Molecular Weight

441.86

Formula

C19H24ClN3O7
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Z-Ala-Ala-Asp-CMK
Sequence Shortening

Z-AAD-CMK
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (226.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2632 mL 11.3158 mL 22.6316 mL
5 mM 0.4526 mL 2.2632 mL 4.5263 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2632 mL 11.3158 mL 22.6316 mL 56.5790 mL
5 mM 0.4526 mL 2.2632 mL 4.5263 mL 11.3158 mL
10 mM 0.2263 mL 1.1316 mL 2.2632 mL 5.6579 mL
15 mM 0.1509 mL 0.7544 mL 1.5088 mL 3.7719 mL
20 mM 0.1132 mL 0.5658 mL 1.1316 mL 2.8290 mL
25 mM 0.0905 mL 0.4526 mL 0.9053 mL 2.2632 mL
30 mM 0.0754 mL 0.3772 mL 0.7544 mL 1.8860 mL
40 mM 0.0566 mL 0.2829 mL 0.5658 mL 1.4145 mL
50 mM 0.0453 mL 0.2263 mL 0.4526 mL 1.1316 mL
60 mM 0.0377 mL 0.1886 mL 0.3772 mL 0.9430 mL
80 mM 0.0283 mL 0.1414 mL 0.2829 mL 0.7072 mL
100 mM 0.0226 mL 0.1132 mL 0.2263 mL 0.5658 mL
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Z-Ala-Ala-Asp-CMK Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z-Ala-Ala-Asp-CMK183284-21-1Z-AAD-CMKCaspaseInhibitorinhibitorinhibit

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