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  4. (Z)-α-Cyanostilbene

(Z)-α-Cyanostilbene (compound 8), a dicyano substituted acrylonitrile, shows selective antiproliferative activity against HeLa and HepG2 cells, with IC50s of 0.33 and 0.52 μM, respectively.

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(Z)-α-Cyanostilbene Chemical Structure

(Z)-α-Cyanostilbene Chemical Structure

CAS No. : 6114-57-4

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(Z)-α-Cyanostilbene Related Antibodies

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Description

(Z)-α-Cyanostilbene (compound 8), a dicyano substituted acrylonitrile, shows selective antiproliferative activity against HeLa and HepG2 cells, with IC50s of 0.33 and 0.52 μM, respectively[1].

Cellular Effect
Cell Line Type Value Description References
A549 IC50
64.6 μM
Compound: 7
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human A549 cells incubated for 72 hrs by MTT assay
[PMID: 31734024]
CFPAC-1 IC50
88.19 μM
Compound: 7
Antiproliferative activity against human CFPAC-1 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human CFPAC-1 cells incubated for 72 hrs by MTT assay
[PMID: 31734024]
HeLa IC50
48.88 μM
Compound: 7
Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HeLa cells incubated for 72 hrs by MTT assay
[PMID: 31734024]
HepG2 IC50
81.51 μM
Compound: 7
Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human HepG2 cells incubated for 72 hrs by MTT assay
[PMID: 31734024]
HFF IC50
93.73 μM
Compound: 7
Cytotoxicity against HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
Cytotoxicity against HFF cells assessed as reduction in cell viability incubated for 72 hrs by MTT assay
[PMID: 31734024]
SW-620 IC50
> 100 μM
Compound: 7
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay
Antiproliferative activity against human SW620 cells incubated for 72 hrs by MTT assay
[PMID: 31734024]
Molecular Weight

205.25

Formula

C15H11N
CAS No.
SMILES

N#C/C(C1=CC=CC=C1)=C\C2=CC=CC=C2
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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(Z)-α-Cyanostilbene Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Z)-α-Cyanostilbene6114-57-4OthersantiproliferativeHeLaHepG2Inhibitorinhibitorinhibit

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