Z32439948

Cat. No.: HY-162340: FAQs
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Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC₅₀: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells.

For research use only. We do not sell to patients.

Z32439948 Chemical Structure

CAS No. : 920845-86-9

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Description

IC₅₀ & Target

BChE

1.4 μM (IC₅₀, ^[1])

In Vitro

Z32439948 (1-5 μM; 48 h) has neuroprotective effects on glutamate (31 mM)-induced SH-SY5Y cell death^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[1]

Cell Line:	SH-SY5Y, BV2 cells
Concentration:	1 μM, 2 μM, 5 μM
Incubation Time:	48 h; with or without 31 mM Glutamate
Result:	Protected cell from Glutamate induced damage.

Molecular Weight

478.56

Formula

C₂₅H₂₆N₄O₄S

CAS No.

920845-86-9

SMILES

O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Lu X, et al. Discovery, Structure-Based Modification, In Vitro, In Vivo, and In Silico Exploration of m-Sulfamoyl Benzoamide Derivatives as Selective Butyrylcholinesterase Inhibitors for Treating Alzheimer's Disease. ACS Chem Neurosci. 2024 Mar 20;15(6):1135-1156. [Content Brief]

Z32439948 Related Classifications

Neurological Disease

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z32439948920845-86-9Z 32439948Z-32439948Cholinesterase (ChE)MetasulfamoylbenzamideneuroprotectionglutamateInhibitorinhibitorinhibit

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