2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Z32439948

Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells.

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Z32439948 Chemical Structure

Z32439948 Chemical Structure

CAS No. : 920845-86-9

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Z32439948 Related Antibodies

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Description

Z32439948 is a butyrylcholinesterase (BChE) inhibitor (IC50: 1.4 μM, hBChE) and is a derivative of m-sulfamoylbenzamide. Z32439948 also exhibited neuroprotective effects against glutamate in SH-SY5Y cells[1].

IC50 & Target

BChE

1.4 μM (IC50, [1])

In Vitro

Z32439948 (1-5 μM; 48 h) has neuroprotective effects on glutamate (31 mM)-induced SH-SY5Y cell death[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z32439948 Related Antibodies

Cell Viability Assay[1]

Cell Line: SH-SY5Y, BV2 cells
Concentration: 1 μM, 2 μM, 5 μM
Incubation Time: 48 h; with or without 31 mM Glutamate
Result: Protected cell from Glutamate induced damage.
Molecular Weight

478.56

Formula

C25H26N4O4S
CAS No.
SMILES

O=C(NCCC1=CNC2=C1C=CC=C2)C3=CC=C(OC)C(S(NCCC4=NC=CC=C4)(=O)=O)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Z32439948 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z32439948920845-86-9Z 32439948Z-32439948Cholinesterase (ChE)MetasulfamoylbenzamideneuroprotectionglutamateInhibitorinhibitorinhibit

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