2. Cell Cycle/DNA Damage
  3. IRE1
  4. Z4P

Z4P is a BBB-penatrable IRE1 inhibitor with an IC50 of 1.13 μM. Z4P in combination with Temozolomide (HY-17364) inhibits the growth and recurrence of glioblastoma and has anti-tumor activity.

For research use only. We do not sell to patients.

Z4P Chemical Structure

Z4P Chemical Structure

CAS No. : 2361760-87-2

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 242 In-stock
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5 mg USD 220 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Z4P Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Z4P

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Z4P is a BBB-penatrable IRE1 inhibitor with an IC50 of 1.13 μM. Z4P in combination with Temozolomide (HY-17364) inhibits the growth and recurrence of glioblastoma and has anti-tumor activity[1].

IC50 & Target

IC50: 1.13 μM (IRE1)[1]
In Vitro

Z4P (0-25 μM; 24 h) inhibits the activity of IRE1 and reduces the phosphorylation level of IRE1 in glioblastoma cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Z4P Related Antibodies
In Vivo

Z4P (300 μg/kg; intraperitoneal injection; 186 days) combined with Temozolomide (HY-17364) shows antitumor activity in a mouse glioblastoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI-Foxn1nu/Foxn1nu mice with glioblastoma[1]
Dosage: 300 μg/kg
Administration: Intraperitoneal injection (i.p.); 186 days
Result: Decreased the splicing of XBP1 mRNA.
Arrested tumor growth.
Prolonged relapse-free survival.
Molecular Weight

312.41

Formula

C19H24N2O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC(CCC1=CC=C(C=C1)O)C)NC2=CC(C)=CC=C2C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (320.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2009 mL 16.0046 mL 32.0092 mL
5 mM 0.6402 mL 3.2009 mL 6.4018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: 2.5 mg/mL (8.00 mM); Clear solution; Need ultrasonic

    This protocol yields a clear solution of 2.5 mg/mL. If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2009 mL 16.0046 mL 32.0092 mL 80.0230 mL
5 mM 0.6402 mL 3.2009 mL 6.4018 mL 16.0046 mL
10 mM 0.3201 mL 1.6005 mL 3.2009 mL 8.0023 mL
15 mM 0.2134 mL 1.0670 mL 2.1339 mL 5.3349 mL
20 mM 0.1600 mL 0.8002 mL 1.6005 mL 4.0012 mL
25 mM 0.1280 mL 0.6402 mL 1.2804 mL 3.2009 mL
30 mM 0.1067 mL 0.5335 mL 1.0670 mL 2.6674 mL
40 mM 0.0800 mL 0.4001 mL 0.8002 mL 2.0006 mL
50 mM 0.0640 mL 0.3201 mL 0.6402 mL 1.6005 mL
60 mM 0.0533 mL 0.2667 mL 0.5335 mL 1.3337 mL
80 mM 0.0400 mL 0.2001 mL 0.4001 mL 1.0003 mL
100 mM 0.0320 mL 0.1600 mL 0.3201 mL 0.8002 mL
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Z4P Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Z4P2361760-87-2IRE1Inositol requiring enzyme 1GlioblastomacancertumorBBB-permeableTemozolomideInhibitorinhibitorinhibit

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