2. Protein Tyrosine Kinase/RTK
  3. Btk
  4. Zanubrutinib-d5

Zanubrutinib-d5  (Synonyms: BGB-3111 d5)

Cat. No.: HY-101474S Purity: ≥99.0%
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Zanubrutinib-d5 is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

For research use only. We do not sell to patients.

Zanubrutinib-d<sub>5</sub> Chemical Structure

Zanubrutinib-d5 Chemical Structure

Size Price Stock Quantity
1 mg USD 1100 In-stock
5 mg USD 2760 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

Zanubrutinib-d5 is deuterium labeled Zanubrutinib. Zanubrutinib is a selective Bruton tyrosine kinase (Btk) inhibitor[1].

Molecular Weight

476.58

Formula

C27H24D5N5O3
Unlabeled CAS

1633350-06-7
Appearance

Solid

Color

White to off-white

SMILES

NC(C1=C2N(N=C1C3=CC=C(OC4=C([2H])C([2H])=C([2H])C([2H])=C4[2H])C=C3)[C@H](C5CCN(C(C=C)=O)CC5)CCN2)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (62.95 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0983 mL 10.4914 mL 20.9828 mL
5 mM 0.4197 mL 2.0983 mL 4.1966 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0983 mL 10.4914 mL 20.9828 mL 52.4571 mL
5 mM 0.4197 mL 2.0983 mL 4.1966 mL 10.4914 mL
10 mM 0.2098 mL 1.0491 mL 2.0983 mL 5.2457 mL
15 mM 0.1399 mL 0.6994 mL 1.3989 mL 3.4971 mL
20 mM 0.1049 mL 0.5246 mL 1.0491 mL 2.6229 mL
25 mM 0.0839 mL 0.4197 mL 0.8393 mL 2.0983 mL
30 mM 0.0699 mL 0.3497 mL 0.6994 mL 1.7486 mL
40 mM 0.0525 mL 0.2623 mL 0.5246 mL 1.3114 mL
50 mM 0.0420 mL 0.2098 mL 0.4197 mL 1.0491 mL
60 mM 0.0350 mL 0.1749 mL 0.3497 mL 0.8743 mL
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Zanubrutinib-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zanubrutinib-d5BGB-3111 d5BtkBruton tyrosine kinasedeuteriumlabeledBrutontyrosinekinaseInhibitorinhibitorinhibit

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