Zinterol (Synonyms: MJ 9184)

Cat. No.: HY-14304: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Zinterol hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Zinterol Chemical Structure

CAS No. : 37000-20-7

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Zinterol:

Zinterol hydrochloride Get quote

1 Publications Citing Use of MCE Zinterol

•Seksjon for farmakologi og farmasøytisk biovitenskap Farmasøytisk institutt Det matematisk-naturvitenskapelige fakultet. 2020 Jul.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Adrenergic Receptor Isoform Specific Products:

View All Isoforms

α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist^[1]. Zinterol increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM^[2].

IC₅₀ & Target

β adrenergic receptor

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.054 nM Compound: Zinterol	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	[PMID: 20804199]

In Vivo

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	In New Zealand White HF rabbits of either sex^[3]
Dosage:	1.0 or 2.5 μg/kg
Administration:	Intravenous bolus administration; over 5 seconds
Result:	2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.

Molecular Weight

378.49

Formula

C₁₉H₂₆N₂O₄S

CAS No.

37000-20-7

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC(C(O)CNC(C)(C)CC2=CC=CC=C2)=CC=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [Content Brief]

[2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca²⁺ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [Content Brief]

[3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. [Content Brief]

Zinterol Related Classifications

Cardiovascular Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinterol37000-20-7MJ 9184MJ9184MJ-9184Adrenergic ReceptorBeta Receptorβ2-adrenoceptorVentriculartachycardiaheartfailureInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks