Zinterol (Synonyms: MJ 9184)

Cat. No.: HY-14304: FAQs
Data Sheet Handling Instructions

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Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Zinterol hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Zinterol Chemical Structure

CAS No. : 37000-20-7

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Other Forms of Zinterol:

Zinterol hydrochloride Get quote

1 Publications Citing Use of MCE Zinterol

•Seksjon for farmakologi og farmasøytisk biovitenskap Farmasøytisk institutt Det matematisk-naturvitenskapelige fakultet. 2020 Jul.

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α adrenergic receptor β adrenergic receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist^[1]. Zinterol increases I_Ca in a concentration-dependent manner with an EC₅₀ of 2.2 nM^[2].

IC₅₀ & Target

β adrenergic receptor

Cellular Effect

Cell Line	Type	Value	Description	References
CHO	EC₅₀	0.054 nM Compound: Zinterol	Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method Agonist activity at human recombinant beta2 adrenergic receptor expressed in CHO cells assessed as elevation in cAMP level after 1 hr by flashplate method	[PMID: 20804199]

In Vivo

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	In New Zealand White HF rabbits of either sex^[3]
Dosage:	1.0 or 2.5 μg/kg
Administration:	Intravenous bolus administration; over 5 seconds
Result:	2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits. 2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.

Molecular Weight

378.49

Formula

C₁₉H₂₆N₂O₄S

CAS No.

37000-20-7

Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC(C(O)CNC(C)(C)CC2=CC=CC=C2)=CC=C1O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Solvent & Solubility

In Vitro:

DMSO : 38 mg/mL (100.40 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6421 mL	13.2104 mL	26.4208 mL
5 mM	0.5284 mL	2.6421 mL	5.2842 mL
10 mM	0.2642 mL	1.3210 mL	2.6421 mL

View the Complete Stock Solution Preparation Table

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Gwee MC, et al. Pharmacological actions of a new -adrenoceptor agonist, MJ-9184-1, in anaesthetized cats. Br J Pharmacol. 1972 Nov;46(3):375-85. [Content Brief]

[2]. Skeberdis VA, et al. Beta-2 adrenergic activation of L-type Ca²⁺ current in cardiac myocytes. J Pharmacol Exp Ther. 1997 Nov;283(2):452-61. [Content Brief]

[3]. Desantiago J, et al. Arrhythmogenic effects of beta2-adrenergic stimulation in the failing heart are attributable to enhanced sarcoplasmic reticulum Ca load. Circ Res. 2008 Jun 6;102(11):1389-97. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.6421 mL	13.2104 mL	26.4208 mL	66.0519 mL
	5 mM	0.5284 mL	2.6421 mL	5.2842 mL	13.2104 mL
	10 mM	0.2642 mL	1.3210 mL	2.6421 mL	6.6052 mL
	15 mM	0.1761 mL	0.8807 mL	1.7614 mL	4.4035 mL
	20 mM	0.1321 mL	0.6605 mL	1.3210 mL	3.3026 mL
	25 mM	0.1057 mL	0.5284 mL	1.0568 mL	2.6421 mL
	30 mM	0.0881 mL	0.4403 mL	0.8807 mL	2.2017 mL
	40 mM	0.0661 mL	0.3303 mL	0.6605 mL	1.6513 mL
	50 mM	0.0528 mL	0.2642 mL	0.5284 mL	1.3210 mL
	60 mM	0.0440 mL	0.2202 mL	0.4403 mL	1.1009 mL
	80 mM	0.0330 mL	0.1651 mL	0.3303 mL	0.8256 mL
	100 mM	0.0264 mL	0.1321 mL	0.2642 mL	0.6605 mL

Zinterol Related Classifications

Cardiovascular Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinterol37000-20-7MJ 9184MJ9184MJ-9184Adrenergic ReceptorBeta Receptorβ2-adrenoceptorVentriculartachycardiaheartfailureInhibitorinhibitorinhibit

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