2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Zinterol

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM.

At equivalent molar concentrations, both the salt and free forms of a compound exhibit comparable biological activity. Nevertheless, the salt form (Zinterol hydrochloride) usually boasts enhanced water solubility and stability.

For research use only. We do not sell to patients.

Zinterol Chemical Structure

Zinterol Chemical Structure

CAS No. : 37000-20-7

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Zinterol Related Antibodies

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Description

Zinterol (MJ 9184) is a potent and selective β2-adrenoceptor agonist[1]. Zinterol increases ICa in a concentration-dependent manner with an EC50 of 2.2 nM[2].

IC50 & Target

β2-adrenoceptor[1]
In Vivo

Zinterol (2.5 μg/kg i.v. bolus over 5 s) leads to ventricular arrhythmias including premature ventricular complexes (PVCs) and runs of ventricular tachycardia (VT) in heart failure (HF) rabbits. Zinterol at a lower dose (1 μg/kg i.v, n=4) does not induce ventricular arrhythmias in HF rabbits[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: In New Zealand White HF rabbits of either sex[3]
Dosage: 1.0 or 2.5 μg/kg
Administration: Intravenous bolus administration; over 5 seconds
Result: 2.5 μg/kg did not significantly alter heart rate or mean arterial blood pressure in either control or HF rabbits.
2.5 μg/kg led to ventricular arrhythmias including PVCs and runs of VT (up to 13 beats long) in 4 of 6 HF rabbits (vs 0 of 5 controls, p<0.01). 1 μg/kg did not induce ventricular arrhythmias in HF rabbits.
Molecular Weight

378.49

Formula

C19H26N2O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CS(=O)(NC1=CC(C(O)CNC(C)(C)CC2=CC=CC=C2)=CC=C1O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

DMSO : 38 mg/mL (100.40 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1.89 mg/mL (4.99 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6421 mL 13.2104 mL 26.4208 mL
5 mM 0.5284 mL 2.6421 mL 5.2842 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 2.6421 mL 13.2104 mL 26.4208 mL 66.0519 mL
DMSO 5 mM 0.5284 mL 2.6421 mL 5.2842 mL 13.2104 mL
10 mM 0.2642 mL 1.3210 mL 2.6421 mL 6.6052 mL
15 mM 0.1761 mL 0.8807 mL 1.7614 mL 4.4035 mL
20 mM 0.1321 mL 0.6605 mL 1.3210 mL 3.3026 mL
25 mM 0.1057 mL 0.5284 mL 1.0568 mL 2.6421 mL
30 mM 0.0881 mL 0.4403 mL 0.8807 mL 2.2017 mL
40 mM 0.0661 mL 0.3303 mL 0.6605 mL 1.6513 mL
50 mM 0.0528 mL 0.2642 mL 0.5284 mL 1.3210 mL
60 mM 0.0440 mL 0.2202 mL 0.4403 mL 1.1009 mL
80 mM 0.0330 mL 0.1651 mL 0.3303 mL 0.8256 mL
100 mM 0.0264 mL 0.1321 mL 0.2642 mL 0.6605 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Zinterol Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Zinterol37000-20-7MJ 9184MJ9184MJ-9184Adrenergic ReceptorBeta Receptorβ2-adrenoceptorVentriculartachycardiaheartfailureInhibitorinhibitorinhibit

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