Ziprasidone hydrochloride (Synonyms: CP-88059 hydrochloride)

Cat. No.: HY-14542A: FAQs
Data Sheet Handling Instructions

Molarity Calculator

Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone hydrochloride has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM).

For research use only. We do not sell to patients.

Ziprasidone hydrochloride Chemical Structure

CAS No. : 122883-93-6

Size		Stock
MOQ		Minimum order quantity
50 mg		Get quote
100 mg		Get quote
250 mg		Get quote
Other size		Get quote

Synthetic products have potential research and development risk.

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other In-stock Forms of Ziprasidone hydrochloride:

Ziprasidone Ziprasidone hydrochloride monohydrate

Other Forms of Ziprasidone hydrochloride:

Ziprasidone In-stock
Ziprasidone hydrochloride monohydrate In-stock
Ziprasidone-d₈ Get quote
Ziprasidone mesylate trihydrate Get quote
Ziprasidone mesylate Get quote
Ziprasidone hydrochloride (Standard) Get quote

1 Publications Citing Use of MCE Ziprasidone hydrochloride

•Research Square Preprint. 2021 Jul.

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms

5-HT₁ Receptor 5-HT₂ Receptor 5-HT₃ Receptor 5-HT₄ Receptor 5-HT₅ Receptor 5-HT₆ Receptor 5-HT₇ Receptor 5-HT Receptor

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms

Dopamine Receptor D₁ Receptor D₂ Receptor D₃ Receptor D₄ Receptor D₅ Receptor

Biological Activity
Purity & Documentation
References
Customer Review

Description

Ziprasidone (CP-88059) hydrochloride is an orally active combined 5-HT and dopamine receptor antagonist^[1]. Ziprasidone hydrochloride has affinities for Rat D₂ (K_i=4.8 nM), 5-HT_2A (K_i=0.42 nM) and 5-HT_1A (K_i=3.4 nM)^[1].

IC₅₀ & Target^[1] ^[1] ^[1]^[2]

Rat 5-HT_2A

0.42 nM (Ki)

Rat 5-HT_1A Receptor

3.4 nM (Ki)

Rat D₂ Receptor

4.8 nM (Ki)

In Vitro

Ziprasidone hydrochloride (0-500 nM, 150 seconds) blocks wild-type hERG current^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay^[2]

Cell Line:	HEK-293 cells
Concentration:	0-500 nM
Incubation Time:	150 seconds
Result:	Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC₅₀ = 120 nm).

In Vivo

Ziprasidone hydrochloride (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g^[3]
Dosage:	20 mg/kg
Administration:	Oral gavage; 20 mg/kg; once daily; 7 weeks
Result:	Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).

Clinical Trial

Molecular Weight

449.40

Formula

C₂₁H₂₂Cl₂N₄OS

CAS No.

122883-93-6

SMILES

ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Rollema H, et al. 5-HT(1A) receptor activation contributes to ziprasidone-induced dopamine release in the rat prefrontal cortex. Biol Psychiatry. 2000;48(3):229-237. [Content Brief]

[2]. Schmidt AW, et al. Ziprasidone: a novel antipsychotic agent with a unique human receptor binding profile. Eur J Pharmacol. 2001;425(3):197-201. [Content Brief]

[3]. Seeger TF, et al. Ziprasidone (CP-88,059): a new antipsychotic with combined dopamine and serotonin receptor antagonist activity. J Pharmacol Exp Ther. 1995;275(1):101-113. [Content Brief]

[4]. Park S, et al. The effect of ziprasidone on body weight and energy expenditure in female rats. Metabolism. 2012;61(6):787-793. [Content Brief]

Ziprasidone hydrochloride Related Classifications

Neurological Disease

Molarity Calculator
Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass		Concentration		Volume		Molecular Weight *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)	×	Volume _(start)	=	Concentration _(final)	×	Volume _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziprasidone122883-93-6CP-88059CP88059CP 880595-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorneuronaluptakeantipsychoticSprague-DawleyratsnorepinephrineInhibitorinhibitorinhibit

Your Recently Viewed Products:

Product Name

Salutation

Applicant Name *

Email Address *

Phone Number *

Organization Name *

Department *

Requested quantity *

Country or Region *

Remarks