2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Ziprasidone mesylate trihydrate

Ziprasidone mesylate trihydrate  (Synonyms: CP-88059 mesylate trihydrate)

Cat. No.: HY-14542B
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Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM).

For research use only. We do not sell to patients.

Ziprasidone mesylate trihydrate Chemical Structure

Ziprasidone mesylate trihydrate Chemical Structure

CAS No. : 199191-69-0

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Ziprasidone mesylate trihydrate Related Antibodies

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Description

Ziprasidone (CP-88059) mesylate trihydrate is an orally active combined 5-HT and dopamine receptor antagonist[1]. Ziprasidone mesylate trihydrate has affinities for Rat D2 (Ki=4.8 nM), 5-HT2A (Ki=0.42 nM) and 5-HT1A (Ki=3.4 nM)[1].

IC50 & Target

Rat 5-HT2 Receptor

0.42 nM (Ki)

Rat 5-HT1A Receptor

3.4 nM (Ki)

Rat D2 Receptor

4.8 nM (Ki)

In Vitro

Ziprasidone mesylate trihydrate (0-500 nM, 150 seconds) blocks wild-type hERG current[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ziprasidone mesylate trihydrate Related Antibodies

Cell Viability Assay

Cell Line: HEK-293 cells[2]
Concentration: 0-500 nM
Incubation Time: 150 seconds
Result: Blocked wild-type hERG current in a voltage- and concentration-dependent manner (IC50 = 120 nm).
In Vivo

Ziprasidone mesylate trihydrate (oral gavage; 20 mg/kg; once daily; 7 weeks) results in weight loss, low level physical activity, high resting energy expenditure and greater capacity for thermogenesis when subjected to cold[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Eight-week-old female Sprague-Dawley rats weighing 200 to 250 g[3]
Dosage: 20 mg/kg
Administration: Oral gavage; 20 mg/kg; once daily; 7 weeks
Result: Gained significantly less weight (P = 0.031), had a lower level of physical activity (P = 0.016), showed a higher resting energy expenditure (P < 0.001), and displayed a greater capacity for thermogenesis when subjected to cold (P < 0.001).
Clinical Trial
Molecular Weight

563.09

Formula

C22H31ClN4O7S2
CAS No.
SMILES

O=S(C)(O)=O.ClC1=CC2=C(CC(N2)=O)C=C1CCN(CC3)CCN3C4=NSC5=C4C=CC=C5.O.O.O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Ziprasidone mesylate trihydrate Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ziprasidone mesylate199191-69-0CP-88059 mesylate5-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine Receptorantipsychotic agent5-HT receptorserotonindopamine receptorHEK-293Inhibitorinhibitorinhibit

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