2. Neuronal Signaling Stem Cell/Wnt PI3K/Akt/mTOR
  3. Cholinesterase (ChE) GSK-3
  4. ZLWH-23

ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease.

For research use only. We do not sell to patients.

ZLWH-23 Chemical Structure

ZLWH-23 Chemical Structure

CAS No. : 2765251-12-3

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ZLWH-23 Related Antibodies

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Description

ZLWH-23 is a selective AChE inhibitor (IC50=0.27 μM) with GSK-3β inhibitory property (IC50=6.78 μM). ZLWH-23 possesses selectivity for AChE over BChE (IC50=20.82 μM) and for GSK-3β over multi-kinases. ZLWH-23 has the potential for the research of Alzheimer's disease[1].

IC50 & Target[1]

GSK-3β

6.78 μM (IC50)

AChE

0.27 μM (IC50)

In Vitro

ZLWH-23 exhibits good selectivity for GSK-3β over multi-kinases and very low cytotoxicity towards SH-SY5Y, HEK-293T, HL-7702, and HepG2 cell lines[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZLWH-23 Related Antibodies
In Vivo

ZLWH-23 displays efficient reduction against tau hyperphosphorylation on Ser-396 site in Tau (P301L) 293T cell model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

513.61

Formula

C30H32FN5O2
CAS No.
SMILES

O=C(C1=CC2=C(C3=CC=NC(NC(C4CC4)=O)=C3N2)C=C1)NCCC5CCN(CC5)CC6=C(C=CC=C6)F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZLWH-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZLWH-232765251-12-3ZLWH23ZLWH 23Cholinesterase (ChE)GSK-3Glycogen synthase kinase-3Glycogen synthase kinase 3GSK-3βselectivelow cytotoxicityTau (P301L) 293T celltau hyperphosphorylationAlzheimer's diseaseInhibitorinhibitorinhibit

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