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ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis.

For research use only. We do not sell to patients.

ZM600 Chemical Structure

ZM600 Chemical Structure

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ZM600 Related Antibodies

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Description

ZM600 is a potent and orally active antihepatic fibrosis agent. ZM600 decreases the LPS (HY-D1056) induced protein expression of collagen I, α-SM, p-p65. ZM600 has the potential for the research of liver fibrosis[1].

In Vitro

ZM600 shows cytotoxicity for LX-2 cells with an IC50 value of 38.17 µM[1].
ZM600 (0, 5, 10, 20 µM; 2+48 h) decreases the protein and mRNA expression of collagen I and α-SM induced by LPS (HY-D1056) and TGF-β1[1].
ZM600 (0, 5, 10, 20 µM; 2+2 h) decreases the LPS (HY-D1056) and TGF-β1 induced protein expression of p-p65, p-Smad2/3 and p-AKT in LX-2 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZM600 Related Antibodies

RT-PCR[1]

Cell Line: LX-2 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 2+48 h
Result: Suppressed LPS (1 µg/mL)-induced protein and mRNA expression of collagen I and α-SMA.

Western Blot Analysis[1]

Cell Line: LX-2 cells
Concentration: 0, 5, 10, 20 µM
Incubation Time: 2+2 h
Result: Decreased the LPS-induced protein expression of p-p65, inhibits TGF-β1-induced phosphorylation of Smad2/3 and AKT in a dose-dependent manner.
In Vivo

ZM600 (15, 30 mg/kg; p.o.; daily for 3 weeks) attenuates CCl4-induced experimental hepatic fibrosis[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 6-8 weeks, 18-20 g, Male C57BL/6J mice[1]
Dosage: 15, 30 mg/kg
Administration: P.o.; daly from the fifth week until 8 weeks
Result: Inhibited the infiltration of inflammatory cells and reduced the edema and necrosis of hepatocytes, decreased the deposition of collagens in liver tissues, decreased positive areas of α-SMA in the livers.
Molecular Weight

504.68

Formula

C33H41FO3
SMILES

[H][C@@]12[C@]([H])([C@@]([H])(CC([C@@]2(CCCC(OC)=O)[H])C(C(C3=CC=C(C(F)=C3)C4=CC=CC=C4)C)=O)CCC5)C5CCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZM600 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZM600ZM 600ZM-600Othersliver fibrosisLX-2 cellsp-p65p-Smad2/3p-AKTTGF-β1LPSorally activeInhibitorinhibitorinhibit

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ZM600
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HY-163778
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