2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. α-CGRP (mouse, rat)

α-CGRP (mouse, rat)  (Synonyms: CGRP (83-119), mouse, rat)

Cat. No.: HY-P0203 Purity: 99.39%
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α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies.

For research use only. We do not sell to patients.

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α-CGRP (mouse, rat) Chemical Structure

α-CGRP (mouse, rat) Chemical Structure

CAS No. : 83651-90-5

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1 mg USD 160 In-stock
5 mg USD 410 In-stock
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50 mg   Get quote  

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Based on 2 publication(s) in Google Scholar

Other Forms of α-CGRP (mouse, rat):

α-CGRP (mouse, rat) Related Antibodies

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Description

α-CGRP (mouse, rat), a neuropeptide (calcitonin gene-related peptide (CGRP)) mainly expressed in neuromuscular junction, is a potent vasodilator. α-CGRP (mouse, rat) can lead to a fall in blood pressure and an increase in heart rate by peripheral administration, also relax colonie smooth muscle. α-CGRP (mouse, rat) has the potential in cardiovascular, pro-inflammatory, migraine and metabolic studies[1][2][3][4].

In Vitro

α-CGRP (mouse, rat) can regulate the innate lymphoid cell response in 2 groups[1].
α-CGRP (mouse, rat) regulates insulin secretion and reduces the risk of type 2 diabetes[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-CGRP (mouse, rat) Related Antibodies
In Vivo

α-CGRP (mouse, rat) (0.25, 0.5, 1 μg/kg/min, intravenous) dose-dependent decreases mean arterial blood pressure, while heart rate and systemic vascular conduction increased, while cardiac output remained unchanged[3].
α-CGRP (mouse, rat) plays an important role in the regulation of Kainic acid (KA) induced pyramid-cell death in hippocampal CA3 region[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

3806.25

Formula

C162H262N50O52S2
CAS No.
Appearance

Solid

Color

White to off-white

Sequence

Ser-Cys-Asn-Thr-Ala-Thr-Cys-Val-Thr-His-Arg-Leu-Ala-Gly-Leu-Leu-Ser-Arg-Ser-Gly-Gly-Val-Val-Lys-Asp-Asn-Phe-Val-Pro-Thr-Asn-Val-Gly-Ser-Glu-Ala-Phe-NH2 (Disulfide bridge:Cys2-Cys7)
Sequence Shortening

SCNTATCVTHRLAGLLSRSGGVVKDNFVPTNVGSEAF-NH2 (Disulfide bridge:Cys2-Cys7)
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 100 mg/mL (26.27 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.2627 mL 1.3136 mL 2.6273 mL
5 mM 0.0525 mL 0.2627 mL 0.5255 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 0.2627 mL 1.3136 mL 2.6273 mL 6.5681 mL
5 mM 0.0525 mL 0.2627 mL 0.5255 mL 1.3136 mL
10 mM 0.0263 mL 0.1314 mL 0.2627 mL 0.6568 mL
15 mM 0.0175 mL 0.0876 mL 0.1752 mL 0.4379 mL
20 mM 0.0131 mL 0.0657 mL 0.1314 mL 0.3284 mL
25 mM 0.0105 mL 0.0525 mL 0.1051 mL 0.2627 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-CGRP (mouse, rat) Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-CGRP (mouse, rat)83651-90-5CGRP (83-119), mouse, ratCGRP ReceptorCalcitonin gene-related peptide receptorvasodilatorcardiovascularpro-inflammatorymigraineInhibitorinhibitorinhibit

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