α-Linolenic acid-d₅

Name: α-Linolenic acid-d 5
Brand: MedChemExpress
SKU: HY-N0728S
Rating: 4.5 (1 reviews)

Cat. No.: HY-N0728S: FAQs
Data Sheet SDS Handling Instructions

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α-Linolenic acid-d₅ is the deuterium labeled α-Linolenic acid. α-Linolenic acid, isolated from seed oils, is an essential fatty acid that cannot be synthesized by humans. α-Linolenic acid can affect the process of thrombotic through the modulation of PI3K/Akt signaling. α-Linolenic acid possess the anti-arrhythmic properties and is related to cardiovascular disease and cancer[1].

For research use only. We do not sell to patients.

α-Linolenic acid-d<sub>5</sub> Chemical Structure

α-Linolenic acid-d₅ Chemical Structure

CAS No. : 145191-04-4

Size	Price	Stock	Quantity
500 μg	USD 646	Get quote 3 - 4 weeks 4 - 5 weeks 2 - 3 weeks	Estimated Time of Arrival: December 31
1 mg		Get quote	Estimated Time of Arrival: December 31
5 mg		Get quote	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of α-Linolenic acid-d₅:

α-Linolenic acid Get quote
α-Linolenic acid-d₁₄ Get quote

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•Related Small Molecules:

•Related Proteins:

View All PI3K Isoform Specific Products:

View All Isoforms

PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

View All Akt Isoform Specific Products:

View All Isoforms

Akt Akt1 Akt2 Akt3

Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

283.46

Formula

C₁₈H₂₅D₅O₂

CAS No.

145191-04-4

Unlabeled CAS

463-40-1

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[2H]C([2H])(C([2H])(/C=C\C/C=C\C/C=C\CCCCCCCC(O)=O)[2H])[2H]

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (352.78 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.5278 mL	17.6392 mL	35.2783 mL
5 mM	0.7056 mL	3.5278 mL	7.0557 mL
10 mM	0.3528 mL	1.7639 mL	3.5278 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Data Sheet (267 KB) SDS (393 KB) Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Yang Q, et al. Anti-thrombotic effects of α-linolenic acid isolated from Zanthoxylum bungeanum Maxim seeds. BMC Complement Altern Med. 2014 Sep 23;14:348. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.5278 mL	17.6392 mL	35.2783 mL	88.1959 mL
	5 mM	0.7056 mL	3.5278 mL	7.0557 mL	17.6392 mL
	10 mM	0.3528 mL	1.7639 mL	3.5278 mL	8.8196 mL
	15 mM	0.2352 mL	1.1759 mL	2.3519 mL	5.8797 mL
	20 mM	0.1764 mL	0.8820 mL	1.7639 mL	4.4098 mL
	25 mM	0.1411 mL	0.7056 mL	1.4111 mL	3.5278 mL
	30 mM	0.1176 mL	0.5880 mL	1.1759 mL	2.9399 mL
	40 mM	0.0882 mL	0.4410 mL	0.8820 mL	2.2049 mL
	50 mM	0.0706 mL	0.3528 mL	0.7056 mL	1.7639 mL
	60 mM	0.0588 mL	0.2940 mL	0.5880 mL	1.4699 mL
	80 mM	0.0441 mL	0.2205 mL	0.4410 mL	1.1024 mL
	100 mM	0.0353 mL	0.1764 mL	0.3528 mL	0.8820 mL