2. Others NF-κB Anti-infection Metabolic Enzyme/Protease Apoptosis
  3. Isotope-Labeled Compounds NF-κB HIV Mitochondrial Metabolism Endogenous Metabolite Apoptosis
  4. α-Lipoic Acid-d5

α-Lipoic Acid-d5  (Synonyms: Thioctic acid-d5; (±)-α-Lipoic acid-d5; DL-α-Lipoic acid-d5)

Cat. No.: HY-N0492S Purity: 96.68%
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α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

For research use only. We do not sell to patients.

α-Lipoic Acid-d<sub>5</sub> Chemical Structure

α-Lipoic Acid-d5 Chemical Structure

CAS No. : 1189471-66-6

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1 mg USD 250 In-stock
5 mg USD 1150 In-stock
10 mg USD 1600 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of α-Lipoic Acid-d5:

α-Lipoic Acid-d5 Related Antibodies

Top Publications Citing Use of Products

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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HIV HIV-1 HIV-2

  • Biological Activity

  • Purity & Documentation

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  • Customer Review

Description

α-Lipoic Acid-d5 is the deuterium labeled α-Lipoic Acid. α-Lipoic Acid is an antioxidant, which is an essential cofactor of mitochondrial enzyme complexes. α-Lipoic Acid inhibits NF-κB-dependent HIV-1 LTR activation[1][2][3]. α-Lipoic Acid induces endoplasmic reticulum (ER) stress-mediated apoptosis in hepatoma cells[4].

IC50 & Target

HIV-1

 

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

α-Lipoic Acid-d5 Related Antibodies
Molecular Weight

211.36

Formula

C8H9D5O2S2
CAS No.
Unlabeled CAS

1077-28-7
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC(CCCC([2H])([2H])C1([2H])C([2H])([2H])CSS1)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (473.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 100 mg/mL (473.13 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 0.1 mg/mL (0.47 mM; Need ultrasonic)

H2O : 0.1 mg/mL (0.47 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7313 mL 23.6563 mL 47.3126 mL
5 mM 0.9463 mL 4.7313 mL 9.4625 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Volume
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 4.7313 mL 23.6563 mL 47.3126 mL 118.2816 mL
5 mM 0.9463 mL 4.7313 mL 9.4625 mL 23.6563 mL
10 mM 0.4731 mL 2.3656 mL 4.7313 mL 11.8282 mL
15 mM 0.3154 mL 1.5771 mL 3.1542 mL 7.8854 mL
20 mM 0.2366 mL 1.1828 mL 2.3656 mL 5.9141 mL
25 mM 0.1893 mL 0.9463 mL 1.8925 mL 4.7313 mL
30 mM 0.1577 mL 0.7885 mL 1.5771 mL 3.9427 mL
40 mM 0.1183 mL 0.5914 mL 1.1828 mL 2.9570 mL
50 mM 0.0946 mL 0.4731 mL 0.9463 mL 2.3656 mL
60 mM 0.0789 mL 0.3943 mL 0.7885 mL 1.9714 mL
80 mM 0.0591 mL 0.2957 mL 0.5914 mL 1.4785 mL
100 mM 0.0473 mL 0.2366 mL 0.4731 mL 1.1828 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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α-Lipoic Acid-d5 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

α-Lipoic Acid-d51189471-66-6Thioctic acid-d5(±)-α-Lipoic acid-d5DL-α-Lipoic acid-d5Isotope-Labeled CompoundsNF-κBHIVMitochondrial MetabolismEndogenous MetaboliteApoptosisNuclear factor-κBNuclear factor-kappaBHuman immunodeficiency virusInhibitorinhibitorinhibit

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