α-Synuclein inhibitor 10

Cat. No.: HY-157308 Purity: 99.85%: FAQs
Data Sheet SDS COA Handling Instructions

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α-Synuclein inhibitor 10 (compound a8) inhibits the activity of α-Syn aggregation with low IC₅₀ value (1.08 μM). α-Synuclein inhibitor 10 exhibits good binding affinity to α-Syn residues. α-Synuclein inhibitor 10 can be used in the research of Parkinson's disease (PD).

For research use only. We do not sell to patients.

α-Synuclein inhibitor 10 Chemical Structure

CAS No. : 3050715-65-3

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5 mg		Check price and availability
10 mg		Check price and availability
25 mg		Check price and availability
50 mg		Check price and availability

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Description

Molecular Weight

409.78

Formula

C₂₁H₁₂ClNO₆

CAS No.

3050715-65-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C(C=C1C2=O)=CC(O)=C1C(C3=C2C=CC=C3O)=O)NC4=CC=C(Cl)C=C4O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (61.01 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.4403 mL	12.2017 mL	24.4033 mL
5 mM	0.4881 mL	2.4403 mL	4.8807 mL
10 mM	0.2440 mL	1.2202 mL	2.4403 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

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Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.85%

Select Batch:

Data Sheet (270 KB) SDS (252 KB)

COA (250 KB) HNMR (216 KB) RP-HPLC (263 KB) LCMS (148 KB)

Handling Instructions (2659 KB)

References

[1]. Wei Zhang, et al. The potential of Rhein's aromatic amines for Parkinson's disease prevention and treatment: α-Synuclein aggregation inhibition and disaggregation of preformed fibers. Bioorg Med Chem Lett. 2024. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.4403 mL	12.2017 mL	24.4033 mL	61.0083 mL
	5 mM	0.4881 mL	2.4403 mL	4.8807 mL	12.2017 mL
	10 mM	0.2440 mL	1.2202 mL	2.4403 mL	6.1008 mL
	15 mM	0.1627 mL	0.8134 mL	1.6269 mL	4.0672 mL
	20 mM	0.1220 mL	0.6101 mL	1.2202 mL	3.0504 mL
	25 mM	0.0976 mL	0.4881 mL	0.9761 mL	2.4403 mL
	30 mM	0.0813 mL	0.4067 mL	0.8134 mL	2.0336 mL
	40 mM	0.0610 mL	0.3050 mL	0.6101 mL	1.5252 mL
	50 mM	0.0488 mL	0.2440 mL	0.4881 mL	1.2202 mL
	60 mM	0.0407 mL	0.2034 mL	0.4067 mL	1.0168 mL