2. PROTAC GPCR/G Protein Neuronal Signaling
  3. PROTACs Adrenergic Receptor
  4. α1A-AR Degrader 9c

α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research.

For research use only. We do not sell to patients.

α1A-AR Degrader 9c Chemical Structure

α1A-AR Degrader 9c Chemical Structure

CAS No. : 2863635-02-1

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Based on 1 publication(s) in Google Scholar

α1A-AR Degrader 9c Related Antibodies

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Description

α1A-AR Degrader 9c (compound 9c) is a potent, selective and reversible α1A-AR (Adrenergic receptor) PROTAC degrader, with a DC50 of 2.86 μM. α1A-AR Degrader 9c induces α1A-AR degradation can be attributed to proteasomal degradation. α1A-AR Degrader 9c inhibits the proliferation of PC-3 cells, with an IC50 of 6.12 μM. α1A-AR Degrader 9c shows antitumor activity, and can be used for prostate cancer research[1].

IC50 & Target

α1A-adrenergic receptor

2.86 μM (DC50)

Cellular Effect
Cell Line Type Value Description References
PC-3 IC50
6.12 μM
Compound: 9c
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
Antiproliferative activity against human PC-3 cells assessed as inhibition of cell proliferation incubated for 48 hrs by CCK8 assay
[PMID: 33160761]
In Vivo

α1A-AR Degrader 9c (compound 9c) (50 mg/kg, IP, once daily for 15 days) causes a significant suppression of tumor growth[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

829.82

Formula

C38H43N11O11
CAS No.
SMILES

O=C(NC1=CC=CC(C(N2C(CC3)C(NC3=O)=O)=O)=C1C2=O)COCCOCCOCCN4N=NC(C(N5CCN(C6=NC(N)=C7C=C(OC)C(OC)=CC7=N6)CC5)=O)=C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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α1A-AR Degrader 9c Related Classifications

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Keywords:

α1A-AR Degrader 9c2863635-02-1PROTACsAdrenergic ReceptorBeta ReceptorPC-3 cellsHEK293 cellssmall-molecule PROTACsα1A-Adrenergic receptorubiquitylationdegradationprostate cancerInhibitorinhibitorinhibit

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