α2C adrenoceptor agonist 1 

α2C adrenoceptor agonist 1 (Compound A) is an orally active, highly selective, and non-central nervous system penetrating agonist for the α2C-adrenoceptor, with EC₅₀ and K_i values of 108 nM and 12 nM, respectively. α2C adrenoceptor agonist 1 can be used in the study of nasal congestion^[1].

α2C adrenoceptor agonist 1 (Compound A) (5 mg/kg; p.o.; single dose) exhibits poor brain permeability in Sprague-Dawley rats, with average values for C_max, T_max, and area under the curve being 0.8 μM, 0.7 h, and 2 μM•h, respectively^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

315.37

C₁₆H₂₁N₅O₂

928115-79-1

O=C(N(CC)C1=CC=C2OCCN(CC3=CN=CN3)C2=C1)NC

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Corboz MR, et al. Pharmacological characterization of a novel α2C-adrenoceptor agonist N-[3,4-dihydro-4-(1H-imidazol-4-ylmethyl)-2H-1, 4-benzoxazin-6-yl]-N-ethyl-N'-methylurea (compound A). J Pharmacol Exp Ther. 2011;337(1):256-266.  [Content Brief]