β-FXR antagonist 1

Cat. No.: HY-151481A Purity: 99.80%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist.

For research use only. We do not sell to patients.

β-FXR antagonist 1 Chemical Structure

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of β-FXR antagonist 1:

FXR antagonist 1 Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

β-FXR antagonist 1 (C 12), an isomer of FXR antagonist 1 (HY-151481) is a FXR antagonist^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
HEK-293T	IC₅₀	> 100 μM Compound: F17	Cytotoxicity against HEK293T cells cotransfected with pCMV-Script-hFXR/pGL4.11-hSHP-Luciferase incubated for 24 hrs in presence of GW4064 by celltiter-blue cell viability assay Cytotoxicity against HEK293T cells cotransfected with pCMV-Script-hFXR/pGL4.11-hSHP-Luciferase incubated for 24 hrs in presence of GW4064 by celltiter-blue cell viability assay	[PMID: 36107013]

Molecular Weight

585.86

Formula

C₃₆H₅₉NO₅

CAS No.

2295804-92-9

Appearance

Solid

Color

White to off-white

SMILES

OC(CNC([C@]12[C@@]([C@@H](CC2)C(C)C)([H])[C@]3([H])[C@@](CC1)([C@]4([C@]([C@@]5([C@@](C(C)([C@H](CC5)OC(CCC)=O)C)([H])CC4)C)([H])CC3)C)C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (170.69 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.7069 mL	8.5345 mL	17.0689 mL
5 mM	0.3414 mL	1.7069 mL	3.4138 mL
10 mM	0.1707 mL	0.8534 mL	1.7069 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.80%

Select Batch:

Data Sheet (268 KB) SDS (252 KB)

COA (249 KB) HNMR (161 KB) CNMR (107 KB) RP-HPLC (212 KB) LCMS (240 KB)

Handling Instructions (2659 KB)

References

[1]. Fajun Nan, et al. Pentacyclic triterpenoid and preparation method thereof, pharmaceutical composition and purposes. Patent CN 109517022 A.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.7069 mL	8.5345 mL	17.0689 mL	42.6723 mL
	5 mM	0.3414 mL	1.7069 mL	3.4138 mL	8.5345 mL
	10 mM	0.1707 mL	0.8534 mL	1.7069 mL	4.2672 mL
	15 mM	0.1138 mL	0.5690 mL	1.1379 mL	2.8448 mL
	20 mM	0.0853 mL	0.4267 mL	0.8534 mL	2.1336 mL
	25 mM	0.0683 mL	0.3414 mL	0.6828 mL	1.7069 mL
	30 mM	0.0569 mL	0.2845 mL	0.5690 mL	1.4224 mL
	40 mM	0.0427 mL	0.2134 mL	0.4267 mL	1.0668 mL
	50 mM	0.0341 mL	0.1707 mL	0.3414 mL	0.8534 mL
	60 mM	0.0284 mL	0.1422 mL	0.2845 mL	0.7112 mL
	80 mM	0.0213 mL	0.1067 mL	0.2134 mL	0.5334 mL
	100 mM	0.0171 mL	0.0853 mL	0.1707 mL	0.4267 mL