1,3-Propanediol

Cat. No.: HY-W017758 Purity: 99.97%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism, which has orally active.

For research use only. We do not sell to patients.

1,3-Propanediol Chemical Structure

CAS No. : 504-63-2

Size	Price	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Liquid
1 g	USD 30	In-stock	Estimated Time of Arrival: December 31
5 g	USD 60	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Other Forms of 1,3-Propanediol:

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Biological Activity
Purity & Documentation
References
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Description

1,3-Propanediol is produced in nature by the fermentation of glycerol in microorganism, which has orally active^[1].

In Vivo

1,3-Propanediol (0-1000 mg/kg, i.g., daily, 90 days) has no effects on the clinical condition, body weights, body weight gains, food consumption, organ weights, hematology or serum chemistry parameters of Crl:CD(SD)BR rats^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

76.09

Formula

C₃H₈O₂

CAS No.

504-63-2

Appearance

Liquid (Density: 1.053 g/cm³)

Color

Colorless to light yellow

SMILES

OCCCO

Structure Classification

Others

Initial Source

Microorganisms

Lactobacillus sp.

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature 3 years

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (1314.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	13.1423 mL	65.7117 mL	131.4233 mL
5 mM	2.6285 mL	13.1423 mL	26.2847 mL
10 mM	1.3142 mL	6.5712 mL	13.1423 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (32.86 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (267 KB) SDS (393 KB)

COA (241 KB) HNMR (115 KB) GC (202 KB)

Handling Instructions (2659 KB)

References

[1]. F. Barbirato, et al. Glycerol fermentation by a new 1,3-propanediol-producing microorganism:Enterobacter agglomerans. Applied Microbiology and Biotechnology volume 43, pages786-793(1995).

[2]. Gingell R, et al. Subchronic toxicity study of 1, 3-propanediol administered orally to rats. International journal of toxicology, 2000, 19(1): 27-32.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	13.1423 mL	65.7117 mL	131.4233 mL	328.5583 mL
	5 mM	2.6285 mL	13.1423 mL	26.2847 mL	65.7117 mL
	10 mM	1.3142 mL	6.5712 mL	13.1423 mL	32.8558 mL
	15 mM	0.8762 mL	4.3808 mL	8.7616 mL	21.9039 mL
	20 mM	0.6571 mL	3.2856 mL	6.5712 mL	16.4279 mL
	25 mM	0.5257 mL	2.6285 mL	5.2569 mL	13.1423 mL
	30 mM	0.4381 mL	2.1904 mL	4.3808 mL	10.9519 mL
	40 mM	0.3286 mL	1.6428 mL	3.2856 mL	8.2140 mL
	50 mM	0.2628 mL	1.3142 mL	2.6285 mL	6.5712 mL
	60 mM	0.2190 mL	1.0952 mL	2.1904 mL	5.4760 mL
	80 mM	0.1643 mL	0.8214 mL	1.6428 mL	4.1070 mL
	100 mM	0.1314 mL	0.6571 mL	1.3142 mL	3.2856 mL

1,3-Propanediol Related Classifications

Others

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,3-Propanediol504-63-2Othersmicroorganismglycerolfermentationorally activeInhibitorinhibitorinhibit

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