2. Immunology/Inflammation
  3. Aryl Hydrocarbon Receptor
  4. 1,4-Dihydroxy-2-naphthoic acid

1,4-Dihydroxy-2-naphthoic acid 

Cat. No.: HY-W014701 Purity: 99.58%
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1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity.

For research use only. We do not sell to patients.

1,4-Dihydroxy-2-naphthoic acid Chemical Structure

1,4-Dihydroxy-2-naphthoic acid Chemical Structure

CAS No. : 31519-22-9

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Based on 1 publication(s) in Google Scholar

1,4-Dihydroxy-2-naphthoic acid Related Antibodies

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Description

1,4-Dihydroxy-2-naphthoic acid is an aryl hydrocarbon receptor (AhR) agonist. 1,4-Dihydroxy-2-naphthoic acid is also a bacterially derived metabolite and has anti-inflammatory activity[1].

Molecular Weight

204.18

Formula

C11H8O4
CAS No.
Appearance

Solid

Color

Gray to brown

SMILES

OC1=CC(C(O)=O)=C(O)C2=CC=CC=C21
Structure Classification
Initial Source

Propionibacterium freudenreichii
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (857.09 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.8976 mL 24.4882 mL 48.9764 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8976 mL 24.4882 mL 48.9764 mL 122.4410 mL
5 mM 0.9795 mL 4.8976 mL 9.7953 mL 24.4882 mL
10 mM 0.4898 mL 2.4488 mL 4.8976 mL 12.2441 mL
15 mM 0.3265 mL 1.6325 mL 3.2651 mL 8.1627 mL
20 mM 0.2449 mL 1.2244 mL 2.4488 mL 6.1220 mL
25 mM 0.1959 mL 0.9795 mL 1.9591 mL 4.8976 mL
30 mM 0.1633 mL 0.8163 mL 1.6325 mL 4.0814 mL
40 mM 0.1224 mL 0.6122 mL 1.2244 mL 3.0610 mL
50 mM 0.0980 mL 0.4898 mL 0.9795 mL 2.4488 mL
60 mM 0.0816 mL 0.4081 mL 0.8163 mL 2.0407 mL
80 mM 0.0612 mL 0.3061 mL 0.6122 mL 1.5305 mL
100 mM 0.0490 mL 0.2449 mL 0.4898 mL 1.2244 mL
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1,4-Dihydroxy-2-naphthoic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1,4-Dihydroxy-2-naphthoic acid31519-22-9Aryl Hydrocarbon ReceptorAhR1,4-DHNACaco2 cellsYAMC cellsInhibitorinhibitorinhibit

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