2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis
  4. 1-Hydroxyanthraquinone

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect.

For research use only. We do not sell to patients.

1-Hydroxyanthraquinone Chemical Structure

1-Hydroxyanthraquinone Chemical Structure

CAS No. : 129-43-1

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1-Hydroxyanthraquinone Related Antibodies

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Description

1-Hydroxyanthraquinone, a naturally occurring compound with oral activity from some plants like Tabebuia avellanedae, exhibits carcinogenic effect[1].

In Vivo

1-Hydroxyanthraquinone (HA) generates strong DNA repair response and is carcinogenic in rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Thirty rats[1].
Dosage: 1% HA in diet.
Administration: Diet.
Result: Associated with decreased weight gain which was particularly marked towards the termination of experiment.
One of the 30 rats in group 1 (experimental group) died of pneumonia 243 days after the start of experiment.
A second rat died in an unnourished state at day 280, demonstrating a large tumor in the colon.
Seven animals of the group died spontaneously or were sacrificed upon becoming moribund between 335 and 462 days.
A total of 21 rats of group 1 survived until the end of experiment (mean value of total intake of HA/rat was 76.8 g).
Molecular Weight

224.21

Formula

C14H8O3
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

O=C(C1=C2C=CC=C1)C3=CC=CC(O)=C3C2=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (74.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.4601 mL 22.3005 mL 44.6010 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.4601 mL 22.3005 mL 44.6010 mL 111.5026 mL
5 mM 0.8920 mL 4.4601 mL 8.9202 mL 22.3005 mL
10 mM 0.4460 mL 2.2301 mL 4.4601 mL 11.1503 mL
15 mM 0.2973 mL 1.4867 mL 2.9734 mL 7.4335 mL
20 mM 0.2230 mL 1.1150 mL 2.2301 mL 5.5751 mL
25 mM 0.1784 mL 0.8920 mL 1.7840 mL 4.4601 mL
30 mM 0.1487 mL 0.7434 mL 1.4867 mL 3.7168 mL
40 mM 0.1115 mL 0.5575 mL 1.1150 mL 2.7876 mL
50 mM 0.0892 mL 0.4460 mL 0.8920 mL 2.2301 mL
60 mM 0.0743 mL 0.3717 mL 0.7434 mL 1.8584 mL
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1-Hydroxyanthraquinone Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Hydroxyanthraquinone129-43-1DNA/RNA SynthesiscarcinogenictumorDNArepairpneumoniaInhibitorinhibitorinhibit

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