1-Methylimidazolidin-2-one (Synonyms: 2-imidazolidinone, 1-methyl-)

Name: 1-Methylimidazolidin-2-one
Brand: MedChemExpress
SKU: HY-W005507
Rating: 4.5 (1 reviews)

Cat. No.: HY-W005507 Purity: 99.23%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Methylimidazolidin-2-one is an organic compound commonly used as a solvent and intermediate. It can play a buffering and stabilizing role in some organic synthesis reactions, and can be used as a solvent in some chemical reactions and industrial production processes. In addition, the compound also has good toxicity and biocompatibility, and is widely used in some medical fields.

For research use only. We do not sell to patients.

1-Methylimidazolidin-2-one Chemical Structure

CAS No. : 694-32-6

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 44	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 44	In-stock	Estimated Time of Arrival: December 31
Solid
500 mg	USD 40	In-stock	Estimated Time of Arrival: December 31
1 g	USD 60	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

In Vitro

1-Methylimidazolidin-2-one is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

100.12

Formula

C₄H₈N₂O

CAS No.

694-32-6

Appearance

Solid

Color

White to off-white

SMILES

O=C1NCCN1C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (998.80 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	9.9880 mL	49.9401 mL	99.8801 mL
5 mM	1.9976 mL	9.9880 mL	19.9760 mL
10 mM	0.9988 mL	4.9940 mL	9.9880 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (24.97 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.97%

Select Batch:

Data Sheet (252 KB) SDS (597 KB)

COA (255 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	9.9880 mL	49.9401 mL	99.8801 mL	249.7004 mL
	5 mM	1.9976 mL	9.9880 mL	19.9760 mL	49.9401 mL
	10 mM	0.9988 mL	4.9940 mL	9.9880 mL	24.9700 mL
	15 mM	0.6659 mL	3.3293 mL	6.6587 mL	16.6467 mL
	20 mM	0.4994 mL	2.4970 mL	4.9940 mL	12.4850 mL
	25 mM	0.3995 mL	1.9976 mL	3.9952 mL	9.9880 mL
	30 mM	0.3329 mL	1.6647 mL	3.3293 mL	8.3233 mL
	40 mM	0.2497 mL	1.2485 mL	2.4970 mL	6.2425 mL
	50 mM	0.1998 mL	0.9988 mL	1.9976 mL	4.9940 mL
	60 mM	0.1665 mL	0.8323 mL	1.6647 mL	4.1617 mL
	80 mM	0.1249 mL	0.6243 mL	1.2485 mL	3.1213 mL
	100 mM	0.0999 mL	0.4994 mL	0.9988 mL	2.4970 mL

1-Methylimidazolidin-2-one Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

1-Methylimidazolidin-2-one694-32-62-imidazolidinone, 1-methyl-Biochemical Assay Reagentsbiochemical assayreagentInhibitorinhibitorinhibit

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1-Methylimidazolidin-2-one (Synonyms: 2-imidazolidinone, 1-methyl-)

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Complete Stock Solution Preparation Table

1-Methylimidazolidin-2-one Related Classifications

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