1-Thio-beta-D-glucose tetraacetate

Name: 1-Thio-beta-D-glucose tetraacetate
Brand: MedChemExpress
SKU: HY-W039865
Rating: 4.5 (1 reviews)

Cat. No.: HY-W039865 Purity: 99.88%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

1-Thio-beta-D-glucose tetraacetate exhibits cytotoxicity in cells HeLa and human ocular lens epithelium CECH with IC₅₀s of >250 and >200 μM. 1-Thio-beta-D-glucose tetraacetate reveals moderate anticancer property.

For research use only. We do not sell to patients.

1-Thio-beta-D-glucose tetraacetate Chemical Structure

CAS No. : 19879-84-6

Size	Stock	Quantity
Free Sample (0.1 - 0.5 mg)	Apply Now
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
HCT-116	IC₅₀	> 500 μM Compound: 6	Antiproliferative activity against p53 deficient human HCT116 cells after 96 hrs by MTS assay Antiproliferative activity against p53 deficient human HCT116 cells after 96 hrs by MTS assay	[PMID: 26890119]
HCT-116	IC₅₀	> 750 μM Compound: 6	Antiproliferative activity against p53 expressing human HCT116 cells after 96 hrs by MTS assay Antiproliferative activity against p53 expressing human HCT116 cells after 96 hrs by MTS assay	[PMID: 26890119]

Molecular Weight

364.37

Formula

C₁₄H₂₀O₉S

CAS No.

19879-84-6

Appearance

Solid

Color

White to off-white

SMILES

CC(O[C@H]1[C@@H]([C@H](O[C@H]([C@@H]1OC(C)=O)S)COC(C)=O)OC(C)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (274.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.7445 mL	13.7223 mL	27.4446 mL
5 mM	0.5489 mL	2.7445 mL	5.4889 mL
10 mM	0.2744 mL	1.3722 mL	2.7445 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (13.72 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.88%

Select Batch:

Data Sheet (275 KB) SDS (393 KB)

COA (254 KB) HNMR (256 KB) RP-HPLC (183 KB) MS (72 KB)

Handling Instructions (2659 KB)

References

[1]. Gálvez J, et al., Use of molecular topology in the selection of new cytostatic drugs[J]. Journal of Molecular Structure: THEOCHEM, 2000, 504(1-3): 241-248.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.7445 mL	13.7223 mL	27.4446 mL	68.6116 mL
	5 mM	0.5489 mL	2.7445 mL	5.4889 mL	13.7223 mL
	10 mM	0.2744 mL	1.3722 mL	2.7445 mL	6.8612 mL
	15 mM	0.1830 mL	0.9148 mL	1.8296 mL	4.5741 mL
	20 mM	0.1372 mL	0.6861 mL	1.3722 mL	3.4306 mL
	25 mM	0.1098 mL	0.5489 mL	1.0978 mL	2.7445 mL
	30 mM	0.0915 mL	0.4574 mL	0.9148 mL	2.2871 mL
	40 mM	0.0686 mL	0.3431 mL	0.6861 mL	1.7153 mL
	50 mM	0.0549 mL	0.2744 mL	0.5489 mL	1.3722 mL
	60 mM	0.0457 mL	0.2287 mL	0.4574 mL	1.1435 mL
	80 mM	0.0343 mL	0.1715 mL	0.3431 mL	0.8576 mL
	100 mM	0.0274 mL	0.1372 mL	0.2744 mL	0.6861 mL