10-DEBC hydrochloride

Name: 10-DEBC hydrochloride
Brand: MedChemExpress
SKU: HY-100654
Rating: 4.5 (1 reviews)

Cat. No.: HY-100654 Purity: 99.82%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC₅₀ of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound.

For research use only. We do not sell to patients.

10-DEBC hydrochloride Chemical Structure

CAS No. : 925681-41-0

Size	Price	Stock	Quantity
5 mg	USD 200	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 320	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of 10-DEBC hydrochloride:

10-DEBC Get quote

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Akt Akt1 Akt2 Akt3

Biological Activity
Purity & Documentation
References
Customer Review

Description

10-DEBC hydrochloride is a selective Akt inhibitor, with an IC₅₀ of 1.28 μM. 10-DEBC hydrochloride is a novel anti-TB compound^[1]^[2].

In Vitro

10-DEBC is found to inhibit the growth of Mtb in whole-cell assay with an IC₅₀ of 12.8 μM, while inhibiting replication of Mtb inside iMACs with an IC₅₀ of 1.5 μM, without host cell toxicity even at the highest concentration of 25 μM^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

381.34

Formula

C₂₀H₂₆Cl₂N₂O

CAS No.

925681-41-0

Appearance

Solid

Color

White to off-white

SMILES

CCN(CC)CCCCN1C2=C(C=CC=C2)OC3=CC=C(Cl)C=C13.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (262.23 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H₂O : 50 mg/mL (131.12 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.6223 mL	13.1117 mL	26.2233 mL
5 mM	0.5245 mL	2.6223 mL	5.2447 mL
10 mM	0.2622 mL	1.3112 mL	2.6223 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.82%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (250 KB) HNMR (254 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Wei Li, et al. More than just a GPCR ligand: structure-based discovery of thioridazine derivatives as Pim-1 kinase inhibitors. Medicinal Chemistry Communications.

[2]. Hyo-Won Han, et al. Drug Discovery Platform Targeting M. tuberculosis with Human Embryonic Stem Cell-Derived Macrophages. Stem Cell Reports. 2019 Dec 10;13(6):980-991. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	2.6223 mL	13.1117 mL	26.2233 mL	65.5583 mL
	5 mM	0.5245 mL	2.6223 mL	5.2447 mL	13.1117 mL
	10 mM	0.2622 mL	1.3112 mL	2.6223 mL	6.5558 mL
	15 mM	0.1748 mL	0.8741 mL	1.7482 mL	4.3706 mL
	20 mM	0.1311 mL	0.6556 mL	1.3112 mL	3.2779 mL
	25 mM	0.1049 mL	0.5245 mL	1.0489 mL	2.6223 mL
	30 mM	0.0874 mL	0.4371 mL	0.8741 mL	2.1853 mL
	40 mM	0.0656 mL	0.3278 mL	0.6556 mL	1.6390 mL
	50 mM	0.0524 mL	0.2622 mL	0.5245 mL	1.3112 mL
	60 mM	0.0437 mL	0.2185 mL	0.4371 mL	1.0926 mL
	80 mM	0.0328 mL	0.1639 mL	0.3278 mL	0.8195 mL
	100 mM	0.0262 mL	0.1311 mL	0.2622 mL	0.6556 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.