2. Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. Lipoxygenase DNA/RNA Synthesis
  4. 12R-LOX-IN-2

12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases.

For research use only. We do not sell to patients.

12R-LOX-IN-2 Chemical Structure

12R-LOX-IN-2 Chemical Structure

CAS No. : 3026677-37-9

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12R-LOX-IN-2 Related Antibodies

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5-LOX 12-LOX 15-LOX

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Description

12R-LOX-IN-2 (compound 7b) is an inhibitor of 12R-lipoxygenase (12R-LOX). 12R-LOX-IN-2 inhibits imiquimod (IMQ)-induced hyperproliferation of psoriatic keratinocytes and suppresses colony formation. 12R-LOX-IN-2 also reduced the protein level of Ki67 and the mRNA expression of IL-17A in IMQ-induced cells. 12R-LOX-IN-2 can be used in research into psoriasis and other skin-related inflammatory diseases[1].

IC50 & Target

12R-lipoxygenase (12R-LOX)[1]
Molecular Weight

271.31

Formula

C19H13NO
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

OC(C1=C2C=CC=C1)=CC=C2C3=NC4=CC=CC=C4C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (460.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6858 mL 18.4291 mL 36.8582 mL
5 mM 0.7372 mL 3.6858 mL 7.3716 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.6858 mL 18.4291 mL 36.8582 mL 92.1455 mL
5 mM 0.7372 mL 3.6858 mL 7.3716 mL 18.4291 mL
10 mM 0.3686 mL 1.8429 mL 3.6858 mL 9.2146 mL
15 mM 0.2457 mL 1.2286 mL 2.4572 mL 6.1430 mL
20 mM 0.1843 mL 0.9215 mL 1.8429 mL 4.6073 mL
25 mM 0.1474 mL 0.7372 mL 1.4743 mL 3.6858 mL
30 mM 0.1229 mL 0.6143 mL 1.2286 mL 3.0715 mL
40 mM 0.0921 mL 0.4607 mL 0.9215 mL 2.3036 mL
50 mM 0.0737 mL 0.3686 mL 0.7372 mL 1.8429 mL
60 mM 0.0614 mL 0.3072 mL 0.6143 mL 1.5358 mL
80 mM 0.0461 mL 0.2304 mL 0.4607 mL 1.1518 mL
100 mM 0.0369 mL 0.1843 mL 0.3686 mL 0.9215 mL
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12R-LOX-IN-2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

12R-LOX-IN-23026677-37-9LipoxygenaseDNA/RNA SynthesisLOX12R-lipoxygenasePsoriasisQuinolineSynthesisInhibitorinhibitorinhibit

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