2. PROTAC
  3. E3 Ligase Ligand-Linker Conjugates
  4. Pomalidomide-PEG4-C-COOH

Pomalidomide-PEG4-C-COOH  (Synonyms: Cereblon Ligand -Linker Conjugates 1; E3 Ligase Ligand-Linker Conjugates 1)

Cat. No.: HY-21930 Purity: 99.10%
COA Handling Instructions

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Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

For research use only. We do not sell to patients.

Pomalidomide-PEG4-C-COOH Chemical Structure

Pomalidomide-PEG4-C-COOH Chemical Structure

CAS No. : 2097938-44-6

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5 mg USD 80 In-stock
10 mg USD 120 In-stock
25 mg USD 220 In-stock
50 mg USD 320 In-stock
100 mg USD 450 In-stock
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Based on 1 publication(s) in Google Scholar

Pomalidomide-PEG4-C-COOH Related Antibodies

Top Publications Citing Use of Products

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von Hippel-Lindau (VHL) MDM2 Cereblon cIAP1 Aryl Hydrocarbon Receptor

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Description

Pomalidomide-PEG4-C-COOH is a synthesized E3 ligase ligand-linker conjugate that incorporates the Pomalidomide based cereblon ligand and 4-unit PEG linker used in PROTAC technology.

IC50 & Target

Cereblon

 

Molecular Weight

507.49

Formula

C23H29N3O10
CAS No.
Appearance

Oil

Color

Light yellow to yellow

SMILES

O=C(N(C(CCC1=O)C(N1)=O)C2=O)C(C2=CC=C3)=C3NCCOCCOCCOCCOCC(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (98.52 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Ethanol : 25 mg/mL (49.26 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.9705 mL 9.8524 mL 19.7048 mL
5 mM 0.3941 mL 1.9705 mL 3.9410 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.10%

COA (243 KB) LCMS (112 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO 1 mM 1.9705 mL 9.8524 mL 19.7048 mL 49.2621 mL
5 mM 0.3941 mL 1.9705 mL 3.9410 mL 9.8524 mL
10 mM 0.1970 mL 0.9852 mL 1.9705 mL 4.9262 mL
15 mM 0.1314 mL 0.6568 mL 1.3137 mL 3.2841 mL
20 mM 0.0985 mL 0.4926 mL 0.9852 mL 2.4631 mL
25 mM 0.0788 mL 0.3941 mL 0.7882 mL 1.9705 mL
30 mM 0.0657 mL 0.3284 mL 0.6568 mL 1.6421 mL
40 mM 0.0493 mL 0.2463 mL 0.4926 mL 1.2316 mL
DMSO 50 mM 0.0394 mL 0.1970 mL 0.3941 mL 0.9852 mL
60 mM 0.0328 mL 0.1642 mL 0.3284 mL 0.8210 mL
80 mM 0.0246 mL 0.1232 mL 0.2463 mL 0.6158 mL
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Pomalidomide-PEG4-C-COOH Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pomalidomide-PEG4-C-COOH2097938-44-6Cereblon Ligand -Linker Conjugates 1 E3 Ligase Ligand-Linker Conjugates 1E3 Ligase Ligand-Linker ConjugatesInhibitorinhibitorinhibit

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