17-Hydroxyisolathyrol

Name: 17-Hydroxyisolathyrol
Brand: MedChemExpress
SKU: HY-N4132
Rating: 4.5 (1 reviews)

Cat. No.: HY-N4132 Purity: 99.20%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

17-Hydroxyisolathyrol is a macrocychc lathyrol derivative isolated from seeds of Euphorbla luthyrrs.

For research use only. We do not sell to patients.

17-Hydroxyisolathyrol Chemical Structure

CAS No. : 93551-00-9

Size	Price	Stock	Quantity
1 mg	USD 96	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 202	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 343	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

17-Hydroxyisolathyrol is a macrocychc lathyrol derivative isolated from seeds of Euphorbla luthyrrs^[1].

Molecular Weight

350.45

Formula

C₂₀H₃₀O₅

CAS No.

93551-00-9

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1[C@](C[C@H](C)[C@@H]2O)(O)[C@]2([H])[C@H](O)/C(CO)=C\C[C@@]3([H])[C@@](C3(C)C)([H])/C=C1\C

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (285.35 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8535 mL	14.2674 mL	28.5347 mL
5 mM	0.5707 mL	2.8535 mL	5.7069 mL
10 mM	0.2853 mL	1.4267 mL	2.8535 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (7.13 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.20%

Select Batch:

Data Sheet (280 KB) SDS (251 KB)

COA (263 KB) HNMR (80 KB) CNMR (90 KB) RP-HPLC (225 KB)

Handling Instructions (2659 KB)

References

[1]. Adolf W, et al. Macrocyclic lathyrane type diterpene esters (jolkinols) from callus cultures and roots of Euphorbia lathyris. Planta Med. 1984 Jun;50(3):259-61. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8535 mL	14.2674 mL	28.5347 mL	71.3369 mL
	5 mM	0.5707 mL	2.8535 mL	5.7069 mL	14.2674 mL
	10 mM	0.2853 mL	1.4267 mL	2.8535 mL	7.1337 mL
	15 mM	0.1902 mL	0.9512 mL	1.9023 mL	4.7558 mL
	20 mM	0.1427 mL	0.7134 mL	1.4267 mL	3.5668 mL
	25 mM	0.1141 mL	0.5707 mL	1.1414 mL	2.8535 mL
	30 mM	0.0951 mL	0.4756 mL	0.9512 mL	2.3779 mL
	40 mM	0.0713 mL	0.3567 mL	0.7134 mL	1.7834 mL
	50 mM	0.0571 mL	0.2853 mL	0.5707 mL	1.4267 mL
	60 mM	0.0476 mL	0.2378 mL	0.4756 mL	1.1889 mL
	80 mM	0.0357 mL	0.1783 mL	0.3567 mL	0.8917 mL
	100 mM	0.0285 mL	0.1427 mL	0.2853 mL	0.7134 mL