2-Bromo-4'-hydroxyacetophenone

Name: 2-Bromo-4'-hydroxyacetophenone
Brand: MedChemExpress
SKU: HY-W002314
Rating: 4.5 (1 reviews)

Cat. No.: HY-W002314 Purity: 98.59%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a K_i of 42 μM.

For research use only. We do not sell to patients.

2-Bromo-4'-hydroxyacetophenone Chemical Structure

CAS No. : 2491-38-5

Size	Price	Stock	Quantity
100 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
250 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
500 mg		Get quote
1 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

2-Bromo-4'-hydroxyacetophenone a PTP1B inhibitor, with a K_i of 42 μM^[1].

IC₅₀ & Target

Ki: 42 μM (PTP1B)^[1].

Molecular Weight

215.04

Formula

C₈H₇BrO₂

CAS No.

2491-38-5

Appearance

Solid

Color

White to off-white

SMILES

OC1=CC=C(C(CBr)=O)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*The compound is unstable in solutions, freshly prepared is recommended.

Solvent & Solubility

In Vitro:

DMSO : 250 mg/mL (1162.57 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Methanol : 125 mg/mL (581.29 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.6503 mL	23.2515 mL	46.5030 mL
5 mM	0.9301 mL	4.6503 mL	9.3006 mL
10 mM	0.4650 mL	2.3251 mL	4.6503 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.08 mg/mL (9.67 mM); Clear solution

This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*The compound is unstable in solutions, freshly prepared is recommended.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 98.59%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) RP-HPLC (243 KB)

Handling Instructions (2659 KB)

References

[1]. Sidhu, Alban, et al. Toward Inhibitors of Protein Tyrosine Phosphatases for Cancer Treatment. Home / Current Enzyme Inhibition, Volume 4, Number 1.

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. The compound is unstable in solutions, freshly prepared is recommended.

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

Methanol / DMSO	1 mM	4.6503 mL	23.2515 mL	46.5030 mL	116.2574 mL
	5 mM	0.9301 mL	4.6503 mL	9.3006 mL	23.2515 mL
	10 mM	0.4650 mL	2.3251 mL	4.6503 mL	11.6257 mL
	15 mM	0.3100 mL	1.5501 mL	3.1002 mL	7.7505 mL
	20 mM	0.2325 mL	1.1626 mL	2.3251 mL	5.8129 mL
	25 mM	0.1860 mL	0.9301 mL	1.8601 mL	4.6503 mL
	30 mM	0.1550 mL	0.7750 mL	1.5501 mL	3.8752 mL
	40 mM	0.1163 mL	0.5813 mL	1.1626 mL	2.9064 mL
	50 mM	0.0930 mL	0.4650 mL	0.9301 mL	2.3251 mL
	60 mM	0.0775 mL	0.3875 mL	0.7750 mL	1.9376 mL
	80 mM	0.0581 mL	0.2906 mL	0.5813 mL	1.4532 mL
	100 mM	0.0465 mL	0.2325 mL	0.4650 mL	1.1626 mL