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  3. Isotope-Labeled Compounds
  4. Dimethylpropiothetin hydrochloride-d6

Dimethylpropiothetin hydrochloride-d6  (Synonyms: s,s-Dimethyl-β-propionic acid thetine-d6)

Cat. No.: HY-W105506S Purity: 99.70%
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(2-Carboxyethyl)dimethylsulfonium-d6 chloride is the deuterium labeled (2-Carboxyethyl)dimethylsulfonium chloride[1].

For research use only. We do not sell to patients.

Dimethylpropiothetin hydrochloride-d<sub>6</sub> Chemical Structure

Dimethylpropiothetin hydrochloride-d6 Chemical Structure

CAS No. : 1246274-70-3

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5 mg USD 90 In-stock
10 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Dimethylpropiothetin hydrochloride-d6:

Dimethylpropiothetin hydrochloride-d6 Related Antibodies

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  • Purity & Documentation

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Description

(2-Carboxyethyl)dimethylsulfonium-d6 chloride is the deuterium labeled (2-Carboxyethyl)dimethylsulfonium chloride[1].

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Dimethylpropiothetin hydrochloride-d6 Related Antibodies
Molecular Weight

176.69

Formula

C5H5D6ClO2S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[2H]C([S+](CCC(O)=O)C([2H])([2H])[2H])([2H])[2H].[Cl-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (282.98 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.6596 mL 28.2981 mL 56.5963 mL
5 mM 1.1319 mL 5.6596 mL 11.3193 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (14.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.5 mg/mL (14.15 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.6596 mL 28.2981 mL 56.5963 mL 141.4907 mL
5 mM 1.1319 mL 5.6596 mL 11.3193 mL 28.2981 mL
10 mM 0.5660 mL 2.8298 mL 5.6596 mL 14.1491 mL
15 mM 0.3773 mL 1.8865 mL 3.7731 mL 9.4327 mL
20 mM 0.2830 mL 1.4149 mL 2.8298 mL 7.0745 mL
25 mM 0.2264 mL 1.1319 mL 2.2639 mL 5.6596 mL
30 mM 0.1887 mL 0.9433 mL 1.8865 mL 4.7164 mL
40 mM 0.1415 mL 0.7075 mL 1.4149 mL 3.5373 mL
50 mM 0.1132 mL 0.5660 mL 1.1319 mL 2.8298 mL
60 mM 0.0943 mL 0.4716 mL 0.9433 mL 2.3582 mL
80 mM 0.0707 mL 0.3537 mL 0.7075 mL 1.7686 mL
100 mM 0.0566 mL 0.2830 mL 0.5660 mL 1.4149 mL
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Dimethylpropiothetin hydrochloride-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Dimethylpropiothetin hydrochloride-d61246274-70-3s,s-Dimethyl-β-propionic acid thetine-d6Isotope-Labeled CompoundsInhibitorinhibitorinhibit

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