2-Chloroacetamide

Name: 2-Chloroacetamide
Brand: MedChemExpress
SKU: HY-W010629
Rating: 4.5 (1 reviews)

Cat. No.: HY-W010629 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Chloroacetamide is a preservative and is a herbicide for both uplands and paddy fields. 2-Chloroacetamide is a biocide in agriculture, glues, paints and coatings. 2-Chloroacetamide inhibits very-long-chain fatty acid elongase.

For research use only. We do not sell to patients.

2-Chloroacetamide Chemical Structure

CAS No. : 79-07-2

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 28	In-stock	Estimated Time of Arrival: December 31
Solid
10 g	USD 25	In-stock	Estimated Time of Arrival: December 31
25 g	USD 40	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of 2-Chloroacetamide:

2-Chloroacetamide-d₄ Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

93.51

Formula

C₂H₄ClNO

CAS No.

79-07-2

Appearance

Solid

Color

White to off-white

SMILES

O=C(N)CCl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (1069.40 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	10.6940 mL	53.4702 mL	106.9404 mL
5 mM	2.1388 mL	10.6940 mL	21.3881 mL
10 mM	1.0694 mL	5.3470 mL	10.6940 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (26.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (26.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (26.74 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (269 KB) SDS (644 KB)

COA (244 KB) HNMR (231 KB) MS (77 KB)

Handling Instructions (2659 KB)

References

[1]. Hidenori Okamoto, et al. Synthesis and Herbicidal Activity of N(1-Arylethenyl)-2-chloroacetamides. Agricultural and Biological Chemistry, Volume 55, 1991-Issue 11.

[2]. A Fonia, et al. Active Sensitization to Chloracetamide. Contact Dermatitis. 2009 Jan;60(1):58-9. [Content Brief]

[3]. Christian Eckermann, et al. Covalent Binding of Chloroacetamide Herbicides to the Active Site Cysteine of Plant Type III Polyketide Synthases. Phytochemistry. 2003 Nov;64(6):1045-54. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	10.6940 mL	53.4702 mL	106.9404 mL	267.3511 mL
	5 mM	2.1388 mL	10.6940 mL	21.3881 mL	53.4702 mL
	10 mM	1.0694 mL	5.3470 mL	10.6940 mL	26.7351 mL
	15 mM	0.7129 mL	3.5647 mL	7.1294 mL	17.8234 mL
	20 mM	0.5347 mL	2.6735 mL	5.3470 mL	13.3676 mL
	25 mM	0.4278 mL	2.1388 mL	4.2776 mL	10.6940 mL
	30 mM	0.3565 mL	1.7823 mL	3.5647 mL	8.9117 mL
	40 mM	0.2674 mL	1.3368 mL	2.6735 mL	6.6838 mL
	50 mM	0.2139 mL	1.0694 mL	2.1388 mL	5.3470 mL
	60 mM	0.1782 mL	0.8912 mL	1.7823 mL	4.4559 mL
	80 mM	0.1337 mL	0.6684 mL	1.3368 mL	3.3419 mL
	100 mM	0.1069 mL	0.5347 mL	1.0694 mL	2.6735 mL