2. Cell Cycle/DNA Damage Apoptosis
  3. Nucleoside Antimetabolite/Analog Thymidylate Synthase
  4. FdUMP triethylammonium

FdUMP triethylammonium  (Synonyms: 2’-Deoxy-5-Fluorouridine 5’-phosphate triethylammonium)

Cat. No.: HY-154508
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FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

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FdUMP triethylammonium Chemical Structure

FdUMP triethylammonium Chemical Structure

CAS No. : 134-46-3

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FdUMP triethylammonium Related Antibodies

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Description

FdUMP triethylammonium is the intracellular active form of 5-fluorouracil (5-FU). 5-FU is converted to FdUMP after being transported into the cell by various enzymes. FdUMP forms a ternary complex with thymidylate synthase and its cofactor 5,10-methylene tetrahydrofolate, inhibiting the activity of thymidylate synthase, which in turn leads to the suppression of DNA synthesis.

Cellular Effect
Cell Line Type Value Description References
CCRF-CEM IC50
0.05 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting
[PMID: 21892829]
CCRF-CEM IC50
1.06 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of NBMPR
[PMID: 21892829]
CCRF-CEM IC50
1.74 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
Cytostatic activity against human CEM cells expressing human ENT1 transporter after 72 hrs by cell counting in presence of dipyridamole
[PMID: 21892829]
CCRF-CEM IC50
3.6 μM
Compound: 4, FdUMP, 5-FdUMP
Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
Cytostatic activity against ENT1 transporter-deficient human CEM cells after 72 hrs by cell counting
[PMID: 21892829]
Molecular Weight

528.55

Formula

C21H42FN4O8P
CAS No.
SMILES

O[C@H]1C[C@H](N(C(N2)=O)C=C(F)C2=O)O[C@@H]1COP(O)(O)=O.CCN(CC)CC.CCN(CC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FdUMP triethylammonium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FdUMP134-46-32’-Deoxy-5-Fluorouridine 5’-phosphateNucleoside Antimetabolite/AnalogThymidylate Synthaseindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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