2. Cell Cycle/DNA Damage
  3. DNA/RNA Synthesis Nucleoside Antimetabolite/Analog
  4. 2'-F-Bz-dC Phosphoramidite

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells.

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2'-F-Bz-dC Phosphoramidite Chemical Structure

2'-F-Bz-dC Phosphoramidite Chemical Structure

CAS No. : 161442-19-9

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Based on 1 publication(s) in Google Scholar

2'-F-Bz-dC Phosphoramidite Related Antibodies

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Description

2'-F-Bz-dC Phosphoramidite can be used in the synthesis of oligoribonucleotide (such as DNA and RNA). 2'-F-Bz-dC Phosphoramidite also used for synthesis antiviral agent to inhibit the replication of virus. 2'-F-Bz-dC Phosphoramidite contains a phosphorothioate backbone, to synthesise antisense oligonucleotide analogs to induce apoptosis in cancer cells[1][2][3].

Molecular Weight

851.90

Formula

C46H51FN5O8P
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

COC1=CC=C(C(C2=CC=C(OC)C=C2)(OC[C@@H]3[C@@H](OP(N(C(C)C)C(C)C)OCCC#N)[C@@H](F)[C@H](N4C=CC(NC(C5=CC=CC=C5)=O)=NC4=O)O3)C6=CC=CC=C6)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (117.38 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.1738 mL 5.8692 mL 11.7385 mL
5 mM 0.2348 mL 1.1738 mL 2.3477 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.1738 mL 5.8692 mL 11.7385 mL 29.3462 mL
5 mM 0.2348 mL 1.1738 mL 2.3477 mL 5.8692 mL
10 mM 0.1174 mL 0.5869 mL 1.1738 mL 2.9346 mL
15 mM 0.0783 mL 0.3913 mL 0.7826 mL 1.9564 mL
20 mM 0.0587 mL 0.2935 mL 0.5869 mL 1.4673 mL
25 mM 0.0470 mL 0.2348 mL 0.4695 mL 1.1738 mL
30 mM 0.0391 mL 0.1956 mL 0.3913 mL 0.9782 mL
40 mM 0.0293 mL 0.1467 mL 0.2935 mL 0.7337 mL
50 mM 0.0235 mL 0.1174 mL 0.2348 mL 0.5869 mL
60 mM 0.0196 mL 0.0978 mL 0.1956 mL 0.4891 mL
80 mM 0.0147 mL 0.0734 mL 0.1467 mL 0.3668 mL
100 mM 0.0117 mL 0.0587 mL 0.1174 mL 0.2935 mL
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2'-F-Bz-dC Phosphoramidite Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-F-Bz-dC Phosphoramidite161442-19-9DNA/RNA SynthesisNucleoside Antimetabolite/AnalogInhibitorinhibitorinhibit

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