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  4. 2'-Fluorothymidine

2'-Fluorothymidine  (Synonyms: 2'-​Deoxy-​2'-​fluoro-​5-​Methyluridine)

Cat. No.: HY-128710 Purity: 99.07%
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2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2).

For research use only. We do not sell to patients.

2'-Fluorothymidine Chemical Structure

2'-Fluorothymidine Chemical Structure

CAS No. : 122799-38-6

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5 mg USD 200 In-stock
10 mg USD 300 In-stock
25 mg USD 530 In-stock
50 mg USD 800 In-stock
100 mg USD 1200 In-stock
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Based on 1 publication(s) in Google Scholar

2'-Fluorothymidine Related Antibodies

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Description

2'-Fluorothymidine (2'-Fluoro-2'-deoxythymidine), a bioisostere of both thymidine (TdR) and methyluridine, is a putative highly selective substrate for thymidine kinase type 2 (TK2)[1].

Molecular Weight

260.22

Formula

C10H13FN2O5
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O)[C@@H](F)[C@H](N2C(NC(C(C)=C2)=O)=O)O1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (480.36 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8429 mL 19.2145 mL 38.4290 mL
5 mM 0.7686 mL 3.8429 mL 7.6858 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8429 mL 19.2145 mL 38.4290 mL 96.0726 mL
5 mM 0.7686 mL 3.8429 mL 7.6858 mL 19.2145 mL
10 mM 0.3843 mL 1.9215 mL 3.8429 mL 9.6073 mL
15 mM 0.2562 mL 1.2810 mL 2.5619 mL 6.4048 mL
20 mM 0.1921 mL 0.9607 mL 1.9215 mL 4.8036 mL
25 mM 0.1537 mL 0.7686 mL 1.5372 mL 3.8429 mL
30 mM 0.1281 mL 0.6405 mL 1.2810 mL 3.2024 mL
40 mM 0.0961 mL 0.4804 mL 0.9607 mL 2.4018 mL
50 mM 0.0769 mL 0.3843 mL 0.7686 mL 1.9215 mL
60 mM 0.0640 mL 0.3202 mL 0.6405 mL 1.6012 mL
80 mM 0.0480 mL 0.2402 mL 0.4804 mL 1.2009 mL
100 mM 0.0384 mL 0.1921 mL 0.3843 mL 0.9607 mL
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2'-Fluorothymidine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2'-Fluorothymidine122799-38-62'-​Deoxy-​2'-​fluoro-​5-​MethyluridineOthersInhibitorinhibitorinhibit

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