2. GPCR/G Protein Neuronal Signaling
  3. Melatonin Receptor
  4. 2-Iodomelatonin

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues.

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2-Iodomelatonin Chemical Structure

2-Iodomelatonin Chemical Structure

CAS No. : 93515-00-5

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10 mM * 1 mL in DMSO
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10 mM * 1 mL in DMSO USD 55 In-stock
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Based on 2 publication(s) in Google Scholar

2-Iodomelatonin Related Antibodies

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MT1 MT2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

2-Iodomelatonin is a potent agonist of melatonin receptor 1 (MT1) with a Ki value of 28 pM, it is more 5-fold selective for MT1  over MT2[1]. 2-iodomelatonin can be used to identify, characterize and localize melatonin binding sites in the brain and peripheral tissues[1].

In Vitro

2-iodomelatonin (0-7.5 μM; 18 hours) shares the protective properties of melatonin, it inhibits cell death of mutant htt ST14A and inhibits the increase in Rip2 expression in stressed mutant htt ST14A cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

2-Iodomelatonin Related Antibodies

Cell Viability Assay[2]

Cell Line: Mutant htt ST14A cell
Concentration: 0 μM; 1 μM; 5 μM; 7.5 μM
Incubation Time: 18 hours
Result: Inhibited mutant htt ST14A cell death.
Molecular Weight

358.17

Formula

C13H15IN2O2
CAS No.
Appearance

Solid

Color

Off-white to yellow

SMILES

CC(NCCC1=C(I)NC2=C1C=C(OC)C=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 30 mg/mL (83.76 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 30 mg/mL (83.76 mM; Need ultrasonic and warming)

Ethanol : 20 mg/mL (55.84 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.7920 mL 13.9599 mL 27.9197 mL
5 mM 0.5584 mL 2.7920 mL 5.5839 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.5 mg/mL (6.98 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.04%

COA (250 KB) LCMS (257 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
Ethanol / DMSO / DMF 1 mM 2.7920 mL 13.9599 mL 27.9197 mL 69.7993 mL
5 mM 0.5584 mL 2.7920 mL 5.5839 mL 13.9599 mL
10 mM 0.2792 mL 1.3960 mL 2.7920 mL 6.9799 mL
15 mM 0.1861 mL 0.9307 mL 1.8613 mL 4.6533 mL
20 mM 0.1396 mL 0.6980 mL 1.3960 mL 3.4900 mL
25 mM 0.1117 mL 0.5584 mL 1.1168 mL 2.7920 mL
30 mM 0.0931 mL 0.4653 mL 0.9307 mL 2.3266 mL
40 mM 0.0698 mL 0.3490 mL 0.6980 mL 1.7450 mL
50 mM 0.0558 mL 0.2792 mL 0.5584 mL 1.3960 mL
DMSO / DMF 60 mM 0.0465 mL 0.2327 mL 0.4653 mL 1.1633 mL
80 mM 0.0349 mL 0.1745 mL 0.3490 mL 0.8725 mL
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2-Iodomelatonin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

2-Iodomelatonin93515-00-5Melatonin ReceptorlocalizemelatoninInhibitorinhibitorinhibit

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