2-Thiopheneacetic acid

Name: 2-Thiopheneacetic acid
Brand: MedChemExpress
SKU: HY-W001142
Rating: 4.5 (1 reviews)

Cat. No.: HY-W001142 Purity: 99.98%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

2-Thiopheneacetic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

For research use only. We do not sell to patients.

2-Thiopheneacetic acid Chemical Structure

CAS No. : 1918-77-0

Size	Price	Stock	Quantity
Free Sample (0.1 - 0.5 mg)		Apply Now
25 g	USD 40	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
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Description

2-Thiopheneacetic acid is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

Molecular Weight

142.18

Formula

C₆H₆O₂S

CAS No.

1918-77-0

Appearance

Solid

Color

Off-white to light brown

SMILES

O=C(O)CC1=CC=CS1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (703.33 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	7.0333 mL	35.1667 mL	70.3334 mL
5 mM	1.4067 mL	7.0333 mL	14.0667 mL
10 mM	0.7033 mL	3.5167 mL	7.0333 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (17.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (17.58 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (246 KB) SDS (476 KB)

COA (251 KB) HNMR (134 KB) RP-HPLC (251 KB)

Handling Instructions (2659 KB)

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	7.0333 mL	35.1667 mL	70.3334 mL	175.8335 mL
	5 mM	1.4067 mL	7.0333 mL	14.0667 mL	35.1667 mL
	10 mM	0.7033 mL	3.5167 mL	7.0333 mL	17.5833 mL
	15 mM	0.4689 mL	2.3444 mL	4.6889 mL	11.7222 mL
	20 mM	0.3517 mL	1.7583 mL	3.5167 mL	8.7917 mL
	25 mM	0.2813 mL	1.4067 mL	2.8133 mL	7.0333 mL
	30 mM	0.2344 mL	1.1722 mL	2.3444 mL	5.8611 mL
	40 mM	0.1758 mL	0.8792 mL	1.7583 mL	4.3958 mL
	50 mM	0.1407 mL	0.7033 mL	1.4067 mL	3.5167 mL
	60 mM	0.1172 mL	0.5861 mL	1.1722 mL	2.9306 mL
	80 mM	0.0879 mL	0.4396 mL	0.8792 mL	2.1979 mL
	100 mM	0.0703 mL	0.3517 mL	0.7033 mL	1.7583 mL