3,5-Dimethoxyphenol (Synonyms: Phloroglucinol Dimethyl Ether)

Name: 3,5-Dimethoxyphenol
Brand: MedChemExpress
SKU: HY-W001117
Rating: 4.5 (1 reviews)

Cat. No.: HY-W001117 Purity: 99.84%: FAQs
Data Sheet SDS COA Handling Instructions

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3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves.

For research use only. We do not sell to patients.

3,5-Dimethoxyphenol Chemical Structure

CAS No. : 500-99-2

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Based on 1 publication(s) in Google Scholar

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Description

3,5-Dimethoxyphenol is a toxin metabolite, found in human consuming yew leaves^[1].

Molecular Weight

154.16

Formula

C₈H₁₀O₃

CAS No.

500-99-2

Appearance

<40°C Solid,>43°C Liquid

Color

Light yellow to brown

SMILES

OC1=CC(OC)=CC(OC)=C1

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Pure form	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (648.68 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	6.4868 mL	32.4338 mL	64.8677 mL
5 mM	1.2974 mL	6.4868 mL	12.9735 mL
10 mM	0.6487 mL	3.2434 mL	6.4868 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (16.22 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.84%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (248 KB) HNMR (254 KB) LCMS (87 KB)

Handling Instructions (2659 KB)

References

[1]. Grobosch T, et al. Fatal poisoning with Taxus baccata: quantification of paclitaxel (taxol A), 10-deacetyltaxol, baccatin III, 10-deacetylbaccatin III, cephalomannine (taxol B), and 3,5-dimethoxyphenol in body fluids by liquid chromatography-tandem mass spectrometry. J Anal Toxicol. 2012 Jan-Feb;36(1):36-43. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	6.4868 mL	32.4338 mL	64.8677 mL	162.1692 mL
	5 mM	1.2974 mL	6.4868 mL	12.9735 mL	32.4338 mL
	10 mM	0.6487 mL	3.2434 mL	6.4868 mL	16.2169 mL
	15 mM	0.4325 mL	2.1623 mL	4.3245 mL	10.8113 mL
	20 mM	0.3243 mL	1.6217 mL	3.2434 mL	8.1085 mL
	25 mM	0.2595 mL	1.2974 mL	2.5947 mL	6.4868 mL
	30 mM	0.2162 mL	1.0811 mL	2.1623 mL	5.4056 mL
	40 mM	0.1622 mL	0.8108 mL	1.6217 mL	4.0542 mL
	50 mM	0.1297 mL	0.6487 mL	1.2974 mL	3.2434 mL
	60 mM	0.1081 mL	0.5406 mL	1.0811 mL	2.7028 mL
	80 mM	0.0811 mL	0.4054 mL	0.8108 mL	2.0271 mL
	100 mM	0.0649 mL	0.3243 mL	0.6487 mL	1.6217 mL

3,5-Dimethoxyphenol Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,5-Dimethoxyphenol500-99-2Phloroglucinol Dimethyl EtherEndogenous Metabolitetoxinmetabolite,fatalpoisoningInhibitorinhibitorinhibit

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3,5-Dimethoxyphenol (Synonyms: Phloroglucinol Dimethyl Ether)

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References

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Complete Stock Solution Preparation Table

3,5-Dimethoxyphenol Related Classifications

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