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  4. 3,5-Dinitrocatechol

3,5-Dinitrocatechol  (Synonyms: OR-486; 3,5-Dinitropyrocatechol)

Cat. No.: HY-100959 Purity: 99.72%
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3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex.

For research use only. We do not sell to patients.

3,5-Dinitrocatechol Chemical Structure

3,5-Dinitrocatechol Chemical Structure

CAS No. : 7659-29-2

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1 mg USD 44 In-stock
5 mg USD 110 In-stock
10 mg USD 170 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

3,5-Dinitrocatechol (OR-486) is a potent catechol-O-methyltransferase inhibitor, with an IC50 of 12 nM. 3,5-Dinitrocatechol can be used in the preparation of the molybdenum (VI)- 3,5-Dinitrocatechol complex[1][2][3].

Molecular Weight

200.11

Formula

C6H4N2O6
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC([N+]([O-])=O)=CC([N+]([O-])=O)=C1O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 125 mg/mL (624.66 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (5.00 mM; ultrasonic and warming and heat to 60°C)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.9973 mL 24.9863 mL 49.9725 mL
5 mM 0.9995 mL 4.9973 mL 9.9945 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 4.9973 mL 24.9863 mL 49.9725 mL 124.9313 mL
DMSO 10 mM 0.4997 mL 2.4986 mL 4.9973 mL 12.4931 mL
15 mM 0.3332 mL 1.6658 mL 3.3315 mL 8.3288 mL
20 mM 0.2499 mL 1.2493 mL 2.4986 mL 6.2466 mL
25 mM 0.1999 mL 0.9995 mL 1.9989 mL 4.9973 mL
30 mM 0.1666 mL 0.8329 mL 1.6658 mL 4.1644 mL
40 mM 0.1249 mL 0.6247 mL 1.2493 mL 3.1233 mL
50 mM 0.0999 mL 0.4997 mL 0.9995 mL 2.4986 mL
60 mM 0.0833 mL 0.4164 mL 0.8329 mL 2.0822 mL
80 mM 0.0625 mL 0.3123 mL 0.6247 mL 1.5616 mL
100 mM 0.0500 mL 0.2499 mL 0.4997 mL 1.2493 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3,5-Dinitrocatechol Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3,5-Dinitrocatechol7659-29-2OR-486 3,5-DinitropyrocatecholOR486OR 486Otherscatechol-O-methyltransferasemolybdenumInhibitorinhibitorinhibit

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