2. PROTAC Metabolic Enzyme/Protease
  3. Molecular Glues Endogenous Metabolite
  4. 3-Indoleacetic acid

3-Indoleacetic acid  (Synonyms: Indole-3-acetic acid; 3-IAA)

Cat. No.: HY-18569 Purity: 99.94%
COA Handling Instructions

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3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis.

For research use only. We do not sell to patients.

3-Indoleacetic acid Chemical Structure

3-Indoleacetic acid Chemical Structure

CAS No. : 87-51-4

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Based on 4 publication(s) in Google Scholar

Other Forms of 3-Indoleacetic acid:

3-Indoleacetic acid Related Antibodies

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Description

3-Indoleacetic acid is is an IAA hormone and growth regulator that can promote plant nutritional growth through processes such as cell expansion, differentiation, morphogenesis, and organogenesis[2].
IC50 & Target

Microbial Metabolite

 

Human Endogenous Metabolite

 

In Vitro

3-Indoleacetic acid promotes the enrichment of salt tolerant bacteria with growth promoting function during the secondary fermentation process of compost[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

3-Indoleacetic acid Related Antibodies
In Vivo

3-Indoleacetic acid (50 g/ha) improves outcrossing rate of diverse rice cytoplasmic male sterile lines and hybrid rice seed production through affecting floral traits[2].
3-Indoleacetic acid (10 mg/kg) improves photosynthetic performance and reduces the toxic effect of cadmium on C. camphora[3].
3-Indoleacetic acid (500 mg/kg, once daily, 14 days, p.o.) exhibits adverse effects on liver and kidney function, myocardial and skeletal muscles, and testes in rats[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: adult male Wistar albino rat[4].
Dosage: 500 mg/kg body weight, once daily, 14 days
Administration: oral gavage (p.o.)
Result: Reduced the number of red blood cells and white blood cells[4].
Molecular Weight

175.18

Formula

C10H9NO2
CAS No.
Appearance

Solid

Color

Off-white to light brown

SMILES

OC(CC1=CNC2=C1C=CC=C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (713.55 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 1 mg/mL (5.71 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.7084 mL 28.5421 mL 57.0841 mL
5 mM 1.1417 mL 5.7084 mL 11.4168 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 2.08 mg/mL (11.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 2.08 mg/mL (11.87 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.08 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (20.8 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.94%

COA (252 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 5.7084 mL 28.5421 mL 57.0841 mL 142.7104 mL
5 mM 1.1417 mL 5.7084 mL 11.4168 mL 28.5421 mL
DMSO 10 mM 0.5708 mL 2.8542 mL 5.7084 mL 14.2710 mL
15 mM 0.3806 mL 1.9028 mL 3.8056 mL 9.5140 mL
20 mM 0.2854 mL 1.4271 mL 2.8542 mL 7.1355 mL
25 mM 0.2283 mL 1.1417 mL 2.2834 mL 5.7084 mL
30 mM 0.1903 mL 0.9514 mL 1.9028 mL 4.7570 mL
40 mM 0.1427 mL 0.7136 mL 1.4271 mL 3.5678 mL
50 mM 0.1142 mL 0.5708 mL 1.1417 mL 2.8542 mL
60 mM 0.0951 mL 0.4757 mL 0.9514 mL 2.3785 mL
80 mM 0.0714 mL 0.3568 mL 0.7136 mL 1.7839 mL
100 mM 0.0571 mL 0.2854 mL 0.5708 mL 1.4271 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-Indoleacetic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-Indoleacetic acid87-51-4Indole-3-acetic acid 3-IAAMolecular GluesEndogenous Metabolitenatural plant hormonesplant growth regulatorphotosynthesisInhibitorinhibitorinhibit

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