2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Dopamine Receptor Endogenous Metabolite
  4. 3-O-Methyldopa-d3

3-O-Methyldopa-d3  (Synonyms: 3-Methoxy-L-tyrosine-d3; 3-O-Methyl-L-DOPA-d3)

Cat. No.: HY-113468AS Purity: ≥99.0%
SDS COA Handling Instructions

Molarity Calculator

3-O-Methyldopa-d3 is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

For research use only. We do not sell to patients.

3-O-Methyldopa-d<sub>3</sub> Chemical Structure

3-O-Methyldopa-d3 Chemical Structure

CAS No. : 586954-09-8

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Based on 1 publication(s) in Google Scholar

Other Forms of 3-O-Methyldopa-d3:

3-O-Methyldopa-d3 Related Antibodies

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Description

3-O-Methyldopa-d3 is deuterium labeled 3-O-Methyldopa. 3-O-Methyldopa is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

Molecular Weight

214.23

Formula

C10H10D3NO4
CAS No.
Unlabeled CAS

300-48-1
Appearance

Solid

Color

Off-white to light yellow

SMILES

N[C@@H](CC1=CC=C(O)C(OC([2H])([2H])[2H])=C1)C(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 16.67 mg/mL (77.81 mM; Need ultrasonic)

H2O : 16.67 mg/mL (77.81 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.6679 mL 23.3394 mL 46.6788 mL
5 mM 0.9336 mL 4.6679 mL 9.3358 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.34%

SDS (251 KB)

COA (247 KB) HNMR (114 KB) RP-HPLC (419 KB) MS (176 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / H2O 1 mM 4.6679 mL 23.3394 mL 46.6788 mL 116.6970 mL
5 mM 0.9336 mL 4.6679 mL 9.3358 mL 23.3394 mL
10 mM 0.4668 mL 2.3339 mL 4.6679 mL 11.6697 mL
15 mM 0.3112 mL 1.5560 mL 3.1119 mL 7.7798 mL
20 mM 0.2334 mL 1.1670 mL 2.3339 mL 5.8349 mL
25 mM 0.1867 mL 0.9336 mL 1.8672 mL 4.6679 mL
30 mM 0.1556 mL 0.7780 mL 1.5560 mL 3.8899 mL
40 mM 0.1167 mL 0.5835 mL 1.1670 mL 2.9174 mL
50 mM 0.0934 mL 0.4668 mL 0.9336 mL 2.3339 mL
60 mM 0.0778 mL 0.3890 mL 0.7780 mL 1.9450 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-O-Methyldopa-d3 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-Methyldopa-d3586954-09-83-Methoxy-L-tyrosine-d33-O-Methyl-L-DOPA-d3Dopamine ReceptorEndogenous MetaboliteDeuteriumlabeledL-DOPACOMTInhibitorinhibitorinhibit

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