2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Dopamine Receptor Endogenous Metabolite
  4. 3-O-Methyldopa

3-O-Methyldopa  (Synonyms: 3-Methoxy-L-tyrosine; 3-O-Methyl-L-DOPA)

Cat. No.: HY-113468A Purity: 98.87%
SDS COA Handling Instructions

Molarity Calculator

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine.

For research use only. We do not sell to patients.

3-O-Methyldopa Chemical Structure

3-O-Methyldopa Chemical Structure

CAS No. : 300-48-1

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 USD 99 In-stock
Solution
10 mM * 1 mL in Water USD 99 In-stock
Solid
5 mg USD 90 In-stock
10 mg USD 145 In-stock
25 mg USD 290 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of 3-O-Methyldopa:

3-O-Methyldopa Related Antibodies

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1 Publications Citing Use of MCE 3-O-Methyldopa

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Description

3-O-Methyldopa (3-Methoxy-L-tyrosine) is a metabolite of L-DOPA which is formed by catechol-O-methyltransferase (COMT). 3-O-Methyldopa competitively inhibits the pharmacodynamics of l-DOPA and dopamine[1].

Molecular Weight

211.21

Formula

C10H13NO4
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

N[C@@H](CC1=CC=C(O)C(OC)=C1)C(O)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

H2O : 10 mg/mL (47.35 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7346 mL 23.6731 mL 47.3462 mL
5 mM 0.9469 mL 4.7346 mL 9.4692 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 10 mg/mL (47.35 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.7346 mL 23.6731 mL 47.3462 mL 118.3656 mL
5 mM 0.9469 mL 4.7346 mL 9.4692 mL 23.6731 mL
10 mM 0.4735 mL 2.3673 mL 4.7346 mL 11.8366 mL
15 mM 0.3156 mL 1.5782 mL 3.1564 mL 7.8910 mL
20 mM 0.2367 mL 1.1837 mL 2.3673 mL 5.9183 mL
25 mM 0.1894 mL 0.9469 mL 1.8938 mL 4.7346 mL
30 mM 0.1578 mL 0.7891 mL 1.5782 mL 3.9455 mL
40 mM 0.1184 mL 0.5918 mL 1.1837 mL 2.9591 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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3-O-Methyldopa Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

3-O-Methyldopa300-48-13-Methoxy-L-tyrosine 3-O-Methyl-L-DOPADopamine ReceptorEndogenous MetaboliteL-DOPACOMTdopaminedecarboxylaseneurotoxiccompetitivelyInhibitorinhibitorinhibit

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