3’-O-t-Bulyldimethylsilylthymidine

Cat. No.: HY-W108399 Purity: ≥97.0%: FAQs
Data Sheet SDS COA Handling Instructions Technical Support

3’-O-t-Bulyldimethylsilylthymidine is a purine nucleoside analog. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

3’-O-t-Bulyldimethylsilylthymidine Chemical Structure

CAS No. : 40733-27-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	Get quote	Estimated Time of Arrival: December 31
250 mg	Get quote	Estimated Time of Arrival: December 31
500 mg	Get quote	Estimated Time of Arrival: December 31
1 g	Get quote
5 g	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
JM1	CC₅₀	400 μM Compound: TBS-T	Concentration required to reduce cell viability of JM cells by 50% Concentration required to reduce cell viability of JM cells by 50%	10.1016/0960-894X(96)00443-X

Molecular Weight

356.49

Formula

C₁₆H₂₈N₂O₅Si

CAS No.

40733-27-5

Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H]1[C@@H](O[Si](C)(C)C(C)(C)C)C[C@H](N2C(NC(C(C)=C2)=O)=O)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (280.51 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.8051 mL	14.0256 mL	28.0513 mL
5 mM	0.5610 mL	2.8051 mL	5.6103 mL
10 mM	0.2805 mL	1.4026 mL	2.8051 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: ≥97.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (251 KB) HNMR (122 KB) LCMS (101 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.8051 mL	14.0256 mL	28.0513 mL	70.1282 mL
	5 mM	0.5610 mL	2.8051 mL	5.6103 mL	14.0256 mL
	10 mM	0.2805 mL	1.4026 mL	2.8051 mL	7.0128 mL
	15 mM	0.1870 mL	0.9350 mL	1.8701 mL	4.6752 mL
	20 mM	0.1403 mL	0.7013 mL	1.4026 mL	3.5064 mL
	25 mM	0.1122 mL	0.5610 mL	1.1221 mL	2.8051 mL
	30 mM	0.0935 mL	0.4675 mL	0.9350 mL	2.3376 mL
	40 mM	0.0701 mL	0.3506 mL	0.7013 mL	1.7532 mL
	50 mM	0.0561 mL	0.2805 mL	0.5610 mL	1.4026 mL
	60 mM	0.0468 mL	0.2338 mL	0.4675 mL	1.1688 mL
	80 mM	0.0351 mL	0.1753 mL	0.3506 mL	0.8766 mL
	100 mM	0.0281 mL	0.1403 mL	0.2805 mL	0.7013 mL