4-Acetylaminoantipyrine

Cat. No.: HY-W268542 Purity: 99.60%: FAQs
Data Sheet
SDS

COA
Handling Instructions Technical Support

4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX). 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation.

For research use only. We do not sell to patients.

4-Acetylaminoantipyrine Chemical Structure

CAS No. : 83-15-8

Size	Stock	Quantity
Free Sample (0.1 - 0.5 mg)	Apply Now
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Other Forms of 4-Acetylaminoantipyrine:

4-Acetamidoantipyrine-d₃ Get quote
4-Acetylaminoantipyrine (Standard) Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

4-Acetylaminoantipyrine (4-AA) is a derivative of antipyrine (HY-B0171). 4-Acetylaminoantipyrine acts as a PGE2-dependent blocker and inhibitor of cyclooxygenase (COX)^[1]. 4-Acetylaminoantipyrine can inhibit Cu/ZnSOD^[2]. 4-Acetylaminoantipyrine can spontaneously bind with bovine serum albumin (BSA) and alter its conformation^[3].

Molecular Weight

245.28

Formula

C₁₃H₁₅N₃O₂

CAS No.

83-15-8

Appearance

Solid

Color

Off-white to light yellow

SMILES

CC1=C(NC(C)=O)C(N(N1C)C2=CC=CC=C2)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (407.70 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.0770 mL	20.3849 mL	40.7697 mL
5 mM	0.8154 mL	4.0770 mL	8.1539 mL
10 mM	0.4077 mL	2.0385 mL	4.0770 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.60%

Select Batch:

Data Sheet (274 KB) SDS (393 KB)

COA (253 KB) HNMR (251 KB) LCMS (94 KB)

Handling Instructions (2659 KB)

References

[1]. Berno CR, et al. Aminoantipyrine reduces toxic and genotoxic effects of doxorubicin, cisplatin, and cyclophosphamide in male mice. Mutat Res Genet Toxicol Environ Mutagen. 2016 Jul;805:19-24. [Content Brief]

[2]. Teng Y, et al. Insights into potentially toxic effects of 4-aminoantipyrine on the antioxidant enzyme copper-zinc superoxide dismutase. J Hazard Mater. 2013 Nov 15;262:318-24. [Content Brief]

[3]. Teng Y, et al. The interaction between 4-aminoantipyrine and bovine serum albumin: multiple spectroscopic and molecular docking investigations. J Hazard Mater. 2011 Jun [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.0770 mL	20.3849 mL	40.7697 mL	101.9243 mL
	5 mM	0.8154 mL	4.0770 mL	8.1539 mL	20.3849 mL
	10 mM	0.4077 mL	2.0385 mL	4.0770 mL	10.1924 mL
	15 mM	0.2718 mL	1.3590 mL	2.7180 mL	6.7950 mL
	20 mM	0.2038 mL	1.0192 mL	2.0385 mL	5.0962 mL
	25 mM	0.1631 mL	0.8154 mL	1.6308 mL	4.0770 mL
	30 mM	0.1359 mL	0.6795 mL	1.3590 mL	3.3975 mL
	40 mM	0.1019 mL	0.5096 mL	1.0192 mL	2.5481 mL
	50 mM	0.0815 mL	0.4077 mL	0.8154 mL	2.0385 mL
	60 mM	0.0679 mL	0.3397 mL	0.6795 mL	1.6987 mL
	80 mM	0.0510 mL	0.2548 mL	0.5096 mL	1.2741 mL
	100 mM	0.0408 mL	0.2038 mL	0.4077 mL	1.0192 mL