4-Chlorocinnamic acid

Cat. No.: HY-Y0729 Purity: 98.99%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth.

For research use only. We do not sell to patients.

4-Chlorocinnamic acid Chemical Structure

CAS No. : 1615-02-7

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 38	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 38	In-stock	Estimated Time of Arrival: December 31
Solid
10 g	USD 35	In-stock	Estimated Time of Arrival: December 31
25 g	USD 70	In-stock	Estimated Time of Arrival: December 31
50 g		Get quote

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Biological Activity
Purity & Documentation
References
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Description

4-Chlorocinnamic acid has inhibitory effects on tyrosinase. 4-Chlorocinnamic acid has antibacterial activity. 4-Chlorocinnamic acid also inhibits Colletotrichum gloeosporioides growth^[1]^[2]^[3].

Molecular Weight

182.60

Formula

C₉H₇ClO₂

CAS No.

1615-02-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C/C1=CC=C(Cl)C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (547.65 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.4765 mL	27.3823 mL	54.7645 mL
5 mM	1.0953 mL	5.4765 mL	10.9529 mL
10 mM	0.5476 mL	2.7382 mL	5.4765 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 5 mg/mL (27.38 mM); Clear solution

This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.98%

Select Batch:

Data Sheet (269 KB) SDS (393 KB)

COA (245 KB) HNMR (95 KB) RP-HPLC (177 KB)

Handling Instructions (2659 KB)

References

[1]. Cui Y, et al. Inhibition kinetics and molecular simulation of p-substituted cinnamic acid derivatives on tyrosinase. Int J Biol Macromol. 2017 Feb;95:1289-1297. [Content Brief]

[2]. Silva RHN, et al. Antimicrobial Activity of 4-Chlorocinnamic Acid Derivatives. Biomed Res Int. 2019 Apr 23;2019:3941242. [Content Brief]

[3]. Kátia Aparecida de Siqueira, et al. Isolation of 4-chlorocinnamic acid from Streptomyces griseocarneus R132, and its inhibition activity against sweet pepper postharvest anthracnose. Biocontrol Science and Technology. Volume 32, 2022-Issue 6

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.4765 mL	27.3823 mL	54.7645 mL	136.9113 mL
	5 mM	1.0953 mL	5.4765 mL	10.9529 mL	27.3823 mL
	10 mM	0.5476 mL	2.7382 mL	5.4765 mL	13.6911 mL
	15 mM	0.3651 mL	1.8255 mL	3.6510 mL	9.1274 mL
	20 mM	0.2738 mL	1.3691 mL	2.7382 mL	6.8456 mL
	25 mM	0.2191 mL	1.0953 mL	2.1906 mL	5.4765 mL
	30 mM	0.1825 mL	0.9127 mL	1.8255 mL	4.5637 mL
	40 mM	0.1369 mL	0.6846 mL	1.3691 mL	3.4228 mL
	50 mM	0.1095 mL	0.5476 mL	1.0953 mL	2.7382 mL
	60 mM	0.0913 mL	0.4564 mL	0.9127 mL	2.2819 mL
	80 mM	0.0685 mL	0.3423 mL	0.6846 mL	1.7114 mL
	100 mM	0.0548 mL	0.2738 mL	0.5476 mL	1.3691 mL