2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. 4-Hydroxyatomoxetine-d3

4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor[1].

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4-Hydroxyatomoxetine-d<sub>3</sub> Chemical Structure

4-Hydroxyatomoxetine-d3 Chemical Structure

CAS No. : 1217686-14-0

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Based on 1 publication(s) in Google Scholar

Other Forms of 4-Hydroxyatomoxetine-d3:

4-Hydroxyatomoxetine-d3 Related Antibodies

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Description

4-Hydroxyatomoxetine-d3 is a deuterium labeled 4-Hydroxyatomoxetine. 4-Hydroxyatomoxetine is an active metabolite of Atomoxetine (Tomoxetine). 4-Hydroxyatomoxetine is metabolized by the enzyme cytochrome P450 2D6 (CYP2D6). Atomoxetine is a potent and selective noradrenal in re-uptake inhibitor[1].

Molecular Weight

274.37

Formula

C17H18D3NO2
CAS No.
Unlabeled CAS

435293-66-6
Appearance

Solid

Color

Light yellow to yellow

SMILES

OC1=CC=C(O[C@@H](C2=CC=CC=C2)CCNC([2H])([2H])[2H])C(C)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (455.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMSO : 125 mg/mL (455.59 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.6447 mL 18.2236 mL 36.4471 mL
5 mM 0.7289 mL 3.6447 mL 7.2894 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / DMSO 1 mM 3.6447 mL 18.2236 mL 36.4471 mL 91.1178 mL
5 mM 0.7289 mL 3.6447 mL 7.2894 mL 18.2236 mL
10 mM 0.3645 mL 1.8224 mL 3.6447 mL 9.1118 mL
15 mM 0.2430 mL 1.2149 mL 2.4298 mL 6.0745 mL
20 mM 0.1822 mL 0.9112 mL 1.8224 mL 4.5559 mL
25 mM 0.1458 mL 0.7289 mL 1.4579 mL 3.6447 mL
30 mM 0.1215 mL 0.6075 mL 1.2149 mL 3.0373 mL
40 mM 0.0911 mL 0.4556 mL 0.9112 mL 2.2779 mL
50 mM 0.0729 mL 0.3645 mL 0.7289 mL 1.8224 mL
60 mM 0.0607 mL 0.3037 mL 0.6075 mL 1.5186 mL
80 mM 0.0456 mL 0.2278 mL 0.4556 mL 1.1390 mL
100 mM 0.0364 mL 0.1822 mL 0.3645 mL 0.9112 mL
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4-Hydroxyatomoxetine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-Hydroxyatomoxetine-d31217686-14-0Adrenergic ReceptorBeta ReceptorInhibitorinhibitorinhibit

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