2. Neuronal Signaling Membrane Transporter/Ion Channel
  3. Sigma Receptor iGluR
  4. 4-PPBP maleate

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection.

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4-PPBP maleate Chemical Structure

4-PPBP maleate Chemical Structure

CAS No. : 201216-39-9

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Based on 1 publication(s) in Google Scholar

4-PPBP maleate Related Antibodies

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Description

4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection[1][2][3].

IC50 & Target

NMDA Receptor

 

In Vitro

4-PPBP maleate elicits ERK1/2 phosphorylation in primary neurons[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

4-PPBP maleate Related Antibodies
In Vivo

4-PPBP maleate (1 μmol/kg; i.v.) decreases brain injury after transient focal ischemia in rats[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male rats weighing 300 to 385 g (Transient focal ischemia model)[2]
Dosage: 1 μmol/kg
Administration: Per hour by continuous intravenous infusion starting 1 hour after the initiation of ischemia and continuing through 22 hours of reperfusion.
Result: Decreased brain injury after transient focal ischemia in rats.
Molecular Weight

409.52

Formula

C25H31NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)/C=C\C(O)=O.N1(CCCCC2=CC=CC=C2)CCC(C3=CC=CC=C3)CC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (610.47 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4419 mL 12.2094 mL 24.4188 mL
5 mM 0.4884 mL 2.4419 mL 4.8838 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4419 mL 12.2094 mL 24.4188 mL 61.0471 mL
5 mM 0.4884 mL 2.4419 mL 4.8838 mL 12.2094 mL
10 mM 0.2442 mL 1.2209 mL 2.4419 mL 6.1047 mL
15 mM 0.1628 mL 0.8140 mL 1.6279 mL 4.0698 mL
20 mM 0.1221 mL 0.6105 mL 1.2209 mL 3.0524 mL
25 mM 0.0977 mL 0.4884 mL 0.9768 mL 2.4419 mL
30 mM 0.0814 mL 0.4070 mL 0.8140 mL 2.0349 mL
40 mM 0.0610 mL 0.3052 mL 0.6105 mL 1.5262 mL
50 mM 0.0488 mL 0.2442 mL 0.4884 mL 1.2209 mL
60 mM 0.0407 mL 0.2035 mL 0.4070 mL 1.0175 mL
80 mM 0.0305 mL 0.1526 mL 0.3052 mL 0.7631 mL
100 mM 0.0244 mL 0.1221 mL 0.2442 mL 0.6105 mL
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4-PPBP maleate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4-PPBP201216-39-9Sigma ReceptoriGluRIonotropic glutamate receptorsneuroprotectiontransientfocalischemiaratsneuronsphosphorylationInhibitorinhibitorinhibit

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