4′-Thiouridine (Synonyms: 1-(4-Thio-beta-D-ribofuranosyl)uracil)

Cat. No.: HY-W113081 Purity: 98.68%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

4′-Thiouridine (1-(4-thio-beta-D-ribofuranosyl)uracil) is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.

For research use only. We do not sell to patients.

4′-Thiouridine Chemical Structure

CAS No. : 6741-73-7

Size	Stock	Quantity
1 mg	In-stock	Estimated Time of Arrival: December 31
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	Get quote
100 mg	Get quote

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Description

Molecular Weight

260.27

Formula

C₉H₁₂N₂O₅S

CAS No.

6741-73-7

Appearance

Solid

Color

White to off-white

SMILES

O=C(N([C@@H]1S[C@H](CO)[C@@H](O)[C@H]1O)C=C2)NC2=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (480.27 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8422 mL	19.2108 mL	38.4216 mL
5 mM	0.7684 mL	3.8422 mL	7.6843 mL
10 mM	0.3842 mL	1.9211 mL	3.8422 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.68%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (253 KB) HNMR (210 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Robak T, Robak P. Purine nucleoside analogs in the treatment of rarer chronic lymphoid leukemias. Curr Pharm Des. 2012;18(23):3373-88. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.8422 mL	19.2108 mL	38.4216 mL	96.0541 mL
	5 mM	0.7684 mL	3.8422 mL	7.6843 mL	19.2108 mL
	10 mM	0.3842 mL	1.9211 mL	3.8422 mL	9.6054 mL
	15 mM	0.2561 mL	1.2807 mL	2.5614 mL	6.4036 mL
	20 mM	0.1921 mL	0.9605 mL	1.9211 mL	4.8027 mL
	25 mM	0.1537 mL	0.7684 mL	1.5369 mL	3.8422 mL
	30 mM	0.1281 mL	0.6404 mL	1.2807 mL	3.2018 mL
	40 mM	0.0961 mL	0.4803 mL	0.9605 mL	2.4014 mL
	50 mM	0.0768 mL	0.3842 mL	0.7684 mL	1.9211 mL
	60 mM	0.0640 mL	0.3202 mL	0.6404 mL	1.6009 mL
	80 mM	0.0480 mL	0.2401 mL	0.4803 mL	1.2007 mL
	100 mM	0.0384 mL	0.1921 mL	0.3842 mL	0.9605 mL

4′-Thiouridine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

4′-Thiouridine6741-73-71-(4-Thio-beta-D-ribofuranosyl)uracilNucleoside Antimetabolite/Analogindolent lymphoid malignanciesantitumorInhibitorinhibitorinhibit

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