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  4. 42-(2-Tetrazolyl)rapamycin

42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

For research use only. We do not sell to patients.

42-(2-Tetrazolyl)rapamycin Chemical Structure

42-(2-Tetrazolyl)rapamycin Chemical Structure

CAS No. : 221877-56-1

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 383 In-stock
Solution
10 mM * 1 mL in DMSO USD 383 In-stock
Solid
5 mg USD 220 In-stock
10 mg USD 360 In-stock
25 mg USD 750 In-stock
50 mg USD 1200 In-stock
100 mg   Get quote  
200 mg   Get quote  

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Other Forms of 42-(2-Tetrazolyl)rapamycin:

42-(2-Tetrazolyl)rapamycin Related Antibodies

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Description

42-(2-Tetrazolyl)rapamycin is a proagent compound of a rapamycin analog extracted from patent US 20080171763 A1, Example 1. Rapamycin is a specific mTOR inhibitor.

Molecular Weight

966.21

Formula

C52H79N5O12
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

[H][C@]1(C(O[C@@]([C@@H](C[C@H]2C[C@@H](OC)[C@@H](N3N=CN=N3)CC2)C)([H])CC([C@@H](/C=C([C@@H](O)[C@H]4OC)\C)C)=O)=O)N(C(C([C@@]5(O)[C@H](C)CC[C@](C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C4=O)OC)([H])O5)=O)=O)CCCC1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 130 mg/mL (134.55 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.0350 mL 5.1749 mL 10.3497 mL
5 mM 0.2070 mL 1.0350 mL 2.0699 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.65%

COA (262 KB) HNMR (555 KB) LCMS (96 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.0350 mL 5.1749 mL 10.3497 mL 25.8743 mL
5 mM 0.2070 mL 1.0350 mL 2.0699 mL 5.1749 mL
10 mM 0.1035 mL 0.5175 mL 1.0350 mL 2.5874 mL
15 mM 0.0690 mL 0.3450 mL 0.6900 mL 1.7250 mL
20 mM 0.0517 mL 0.2587 mL 0.5175 mL 1.2937 mL
25 mM 0.0414 mL 0.2070 mL 0.4140 mL 1.0350 mL
30 mM 0.0345 mL 0.1725 mL 0.3450 mL 0.8625 mL
40 mM 0.0259 mL 0.1294 mL 0.2587 mL 0.6469 mL
50 mM 0.0207 mL 0.1035 mL 0.2070 mL 0.5175 mL
60 mM 0.0172 mL 0.0862 mL 0.1725 mL 0.4312 mL
80 mM 0.0129 mL 0.0647 mL 0.1294 mL 0.3234 mL
100 mM 0.0103 mL 0.0517 mL 0.1035 mL 0.2587 mL
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42-(2-Tetrazolyl)rapamycin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

42-(2-Tetrazolyl)rapamycin221877-56-1OthersInhibitorinhibitorinhibit

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