5-Aminouridine

Cat. No.: HY-130802 Purity: 99.31%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

5-Aminouridine can modify nucleobases and can be incorporated into the target DNA. 5-Aminouridine exhibits a wide range of biological activity and it inhibits the growth of tumors, fungi and viruses.

For research use only. We do not sell to patients.

5-Aminouridine Chemical Structure

CAS No. : 2149-76-0

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

This modified nucleobase, 5-Aminouridine, must exhibit a low enough potential to be oxidized by Os(bpy)₃³⁺. These modified nucleobases can be inserted into the target DNA by direct synthesis using modified phosphoramidites^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

5-Aminouridine inhibits incorporation of carbamylaspartate into pyrimidines of both RNA and DNA in rat lived and [³²P]phosphate into phospholipids and RNA nucleotides of rat liver slices and hepatoma^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

259.22

Formula

C₉H₁₃N₃O₆

CAS No.

2149-76-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

OC[C@@H]1[C@@H](O)[C@@H](O)[C@H](N(C(N2)=O)C=C(N)C2=O)O1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility

In Vitro:

H₂O : 25 mg/mL (96.44 mM; Need ultrasonic)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.8577 mL	19.2886 mL	38.5773 mL
5 mM	0.7715 mL	3.8577 mL	7.7155 mL
10 mM	0.3858 mL	1.9289 mL	3.8577 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.31%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (254 KB) HNMR (252 KB) RP-HPLC (276 KB) MS (68 KB)

Handling Instructions (2659 KB)

References

[1]. Smith DA, et al. Studies on 5-aminouridine. Biochim Biophys Acta. 1966 May 19;119(2):221-8. [Content Brief]

[2]. ROBERTS M, et al. Antimetabolite activity of uridine and cytidine derivatives. J Biol Chem. 1952 Feb;194(2):695-701. PMID: 14927662.. . . [Content Brief]

[3]. ROBERTS M, et al. Antimetabolite activity of uridine and cytidine derivatives. J Biol Chem. 1952 Feb;194(2):695-701.

[4]. MR, et al. Detection of attomole quantities [correction of quantitites] of DNA targets on gold microelectrodes by electrocatalytic nucleobase oxidation. Anal Chem. 2003 Dec 1;75(23):6586-92. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O	1 mM	3.8577 mL	19.2886 mL	38.5773 mL	96.4432 mL
	5 mM	0.7715 mL	3.8577 mL	7.7155 mL	19.2886 mL
	10 mM	0.3858 mL	1.9289 mL	3.8577 mL	9.6443 mL
	15 mM	0.2572 mL	1.2859 mL	2.5718 mL	6.4295 mL
	20 mM	0.1929 mL	0.9644 mL	1.9289 mL	4.8222 mL
	25 mM	0.1543 mL	0.7715 mL	1.5431 mL	3.8577 mL
	30 mM	0.1286 mL	0.6430 mL	1.2859 mL	3.2148 mL
	40 mM	0.0964 mL	0.4822 mL	0.9644 mL	2.4111 mL
	50 mM	0.0772 mL	0.3858 mL	0.7715 mL	1.9289 mL
	60 mM	0.0643 mL	0.3215 mL	0.6430 mL	1.6074 mL
	80 mM	0.0482 mL	0.2411 mL	0.4822 mL	1.2055 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

5-Aminouridine Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Aminouridine2149-76-0FungalInfluenza VirusDNAtargetnucleobasespyrimidinesanti-tumorfungivirusesInhibitorinhibitorinhibit

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