2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. 5-Carboxamidotryptamine

5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice.

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5-Carboxamidotryptamine Chemical Structure

5-Carboxamidotryptamine Chemical Structure

CAS No. : 74885-09-9

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5-Carboxamidotryptamine Related Antibodies

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Description

5-Carboxamidotryptamine (5-CT) is a 5-HT1A, 5-HT1B, 5-HT1D, 5-HT5A, 5-HT7 receptor agonist[1][2][3][4]. 5-Carboxamidotryptamine has a Ki value of 4.6 nM for cloned human 5-HT5A receptor. 5-Carboxamidotryptamine causes a dose-dependent reduction in rectal temperature of mice[3][4].

IC50 & Target[1][2][3][4]

5-HT1A Receptor

 

5-HT1B Receptor

 

5-HT1D Receptor

 

5-HT5A Receptor

 

5-HT7 Receptor

 

In Vivo

5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Swiss Webster mice (20-25 g)[3]
Dosage: 0.03-3 mg/kg (i.p.) and 0.125-5 µg (i.c.v.)
Administration: i.p. and i.c.v.
Result: Caused dose-dependent reduction in rectal temperature.
Animal Model: 5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3]
Dosage: 0.1-1 mg/kg
Administration: i.p. and i.c.v.
Result: Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice.
Molecular Weight

203.24

Formula

C11H13N3O
CAS No.
SMILES

O=C(C1=CC2=C(NC=C2CCN)C=C1)N
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Storage

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Purity & Documentation
References
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5-Carboxamidotryptamine Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Carboxamidotryptamine74885-09-95-CT5-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptorrectal temperaturedose-dependentmicerat5-HT7 receptor knockoutInhibitorinhibitorinhibit

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