5-Fluoromethylornithine dihydrochloride (Synonyms: 5-FMOrn dihydrochloride)

Name: 5-Fluoromethylornithine dihydrochloride
Brand: MedChemExpress
SKU: HY-154021A
Rating: 4.5 (1 reviews)

Cat. No.: HY-154021A Purity: 99.08%: FAQs
Data Sheet SDS COA Handling Instructions

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5-Fluoromethylornithine (5-FMOrn) dihydrochloride is a specific irreversible inhibitor of L-ornithine:2-oxoacid aminotransferase (OAT). 5-Fluoromethylornithine dihydrochloride can be used in the study of gyrate atrophy of choroid and retina.

For research use only. We do not sell to patients.

5-Fluoromethylornithine dihydrochloride Chemical Structure

CAS No. : 124796-41-4

Size	Price	Stock	Quantity
5 mg	USD 430	In-stock	Estimated Time of Arrival: December 31
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50 mg		Get quote

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Based on 1 publication(s) in Google Scholar

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Description

Molecular Weight

237.10

Formula

C₆H₁₅Cl₂FN₂O₂

CAS No.

124796-41-4

Appearance

Solid

Color

White to light yellow

SMILES

NC(CCC(N)CF)C(O)=O.[H]Cl.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, stored under nitrogen, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture)

Solvent & Solubility

In Vitro:

H₂O : 100 mg/mL (421.76 mM; Need ultrasonic)

DMSO : 100 mg/mL (421.76 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.2176 mL	21.0881 mL	42.1763 mL
5 mM	0.8435 mL	4.2176 mL	8.4353 mL
10 mM	0.4218 mL	2.1088 mL	4.2176 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (stored under nitrogen, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (10.54 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: 99.08%

Select Batch:

Data Sheet (271 KB) SDS (393 KB)

COA (247 KB) HNMR (246 KB) RP-HPLC (246 KB) MS (80 KB)

Handling Instructions (2659 KB)

References

[1]. Daune G, et al. 5-Fluoromethylornithine, an irreversible and specific inhibitor of L-ornithine:2-oxo-acid aminotransferase. Biochem J. 1988 Jul 15;253(2):481-8. [Content Brief]

[2]. Nakauchi T, et al. Prevention of ornithine cytotoxicity by nonpolar side chain amino acids in retinal pigment epithelial cells. Invest Ophthalmol Vis Sci. 2003 Nov;44(11):5023-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

H₂O / DMSO	1 mM	4.2176 mL	21.0881 mL	42.1763 mL	105.4407 mL
	5 mM	0.8435 mL	4.2176 mL	8.4353 mL	21.0881 mL
	10 mM	0.4218 mL	2.1088 mL	4.2176 mL	10.5441 mL
	15 mM	0.2812 mL	1.4059 mL	2.8118 mL	7.0294 mL
	20 mM	0.2109 mL	1.0544 mL	2.1088 mL	5.2720 mL
	25 mM	0.1687 mL	0.8435 mL	1.6871 mL	4.2176 mL
	30 mM	0.1406 mL	0.7029 mL	1.4059 mL	3.5147 mL
	40 mM	0.1054 mL	0.5272 mL	1.0544 mL	2.6360 mL
	50 mM	0.0844 mL	0.4218 mL	0.8435 mL	2.1088 mL
	60 mM	0.0703 mL	0.3515 mL	0.7029 mL	1.7573 mL
	80 mM	0.0527 mL	0.2636 mL	0.5272 mL	1.3180 mL
	100 mM	0.0422 mL	0.2109 mL	0.4218 mL	1.0544 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

5-Fluoromethylornithine dihydrochloride Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

5-Fluoromethylornithine124796-41-45-FMOrnOATOrganic anion transportergyrate atrophy of choroid and retinaInhibitorinhibitorinhibit

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5-Fluoromethylornithine dihydrochloride (Synonyms: 5-FMOrn dihydrochloride)

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Complete Stock Solution Preparation Table

5-Fluoromethylornithine dihydrochloride Related Classifications

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